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(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone (Dapagliflozin Stage-1)

(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone (Dapagliflozin Stage-1)

CAS Number: 461432-22-4

Molecular Formula: C15H12BrClO2

Dapagliflozin Stage-1 intermediate supplier

About (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone (Dapagliflozin Stage-1)

The synthesis of (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone (CAS 461432-22-4) requires precise control over Friedel-Crafts acylation and subsequent purification protocols to ensure the stringent impurity profiles required for pharmaceutical-grade chemicals. Our GMP manufacturing capabilities allow us to manage t...

(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone (Dapagliflozin Stage-1) Specifications

CAS Number
461432-22-4
Molecular Formula
C15H12BrClO2
Molecular Weight
339.61 g/mol
IUPAC Name
(5-bromo-2-chlorophenyl)-(4-ethoxyphenyl)methanone
Canonical SMILES
CCOC1=CC=C(C=C1)C(=O)C2=C(C=CC(=C2)Br)Cl
InChI Key
OEURLNJEQCLGPS-UHFFFAOYSA-N
InChI
1S/C15H12BrClO2/c1-2-19-12-6-3-10(4-7-12)15(18)13-9-11(16)5-8-14(13)17/h3-9H,2H2,1H3
MDL Number
MFCD11044417
Molecular Weight
339.61 g/mol
Appearance
Off-White to Light Yellow Powder
Melting Point
72 - 76 °C
Solubility
Soluble in DMSO, Chloroform, Ethyl Acetate

SGLT2 Inhibitor Development

Primary precursor for the synthesis of C-glycoside derivatives used in the management of Type 2 diabetes

Medicinal Chemistry & SAR Studies

Versatile scaffold for the introduction of various functional groups via cross-coupling reactions (e.g., Suzuki, Heck, or Buchwald-Hartwig) at the bromo-site

Advanced Intermediate for APIs

Preferred in the multi-stage synthesis of proprietary drug candidates, offering high regiospecificity and structural integrity for downstream transformations

Fine Chemical Synthesis

Essential building block in the development of specialised agrochemicals and advanced materials requiring halogenated diaryl structures

Custom R&D Synthesis

Supports high-throughput screening and early-phase drug discovery by providing consistent, high-purity molecular frameworks

COA
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(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone (Dapagliflozin Stage-1) FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

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US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

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