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4-Cyanopyridine (4-cp)

4-Cyanopyridine (4-cp)

CAS Number: 100-48-1

Molecular Formula: C6H4N2

Isoniazid intermediateTopiroxostat IntermediateDMAP PrecursorAPI Building BlockHeterocyclic PrecursorNitrile HydrolysisAmmoxidation ProductPyridine CarbonitrileFine Chemical Intermediate

About 4-Cyanopyridine (4-cp)

4-Cyanopyridine, also known as isonicotinonitrile or pyridine-4-carbonitrile (CAS 100-48-1, C6H4N2, molecular weight 104.11 g/mol), is a functionalized pyridine building block combining an aromatic pyridine ring with a reactive nitrile group at the 4-position, symmetrically opposite the ring nitrogen, a geometry that s...

Synonyms

  • isonicotinonitril-
  • 4-Cyanopiperidine
  • 4-Dimethylaminopyridine
  • C6H4N2
  • AC1L1OWY
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4-Cyanopyridine (4-cp) Specifications

CAS Number
100-48-1
Molecular Formula
C6H4N2
Molecular Weight
104.109
IUPAC Name
pyridine-4-carbonitrile
Canonical SMILES
C1=CN=CC=C1C#N
InChI Key
GPHQHTOMRSGBNZ-UHFFFAOYSA-N
InChI
1S/C6H4N2/c7-5-6-1-3-8-4-2-6/h1-4H
EINECS Number
202-856-2
MDL Number
MFCD00006417
HSN No
2933.39
Molecular Weight
104.109
Physical State
white to off-white crystalline powder
Density
1.12g/cm3
Boiling Point
196ºC
Melting Point
77-81ºC
Flash Point
88ºC
Refractive Index
1.539
Water Solubility
3.2 g/100ml (16.4 ºC)
GHS Hazard Statements
H302 (94.9%): Harmful if swallowed H312 (58.2%): Harmful in contact with skin H319 (43%): Causes serious eye irritation H332 (58.2%): Harmful if inhaled
Precautionary Statement Codes
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P321, P330, P337+P317, P362+P364, and P501

Pharmaceuticals

Key Intermediate in the synthesis of a variety of drugs. The nitrile (-CN) group is readily hydrolyzed to a carboxylic acid (-COOH) or reduced to an amine (-CH2NH2)

Fine & Specialty Chemicals

Precursor for the synthesis of complex pyridine derivatives, including the powerful nucleophilic catalyst 4-Dimethylaminopyridine (DMAP)

Agrochemicals

Intermediate in the development of certain pesticides and herbicides that incorporate the pyridine ring structure.

Pharmaceutical Intermediate

An important fine chemical intermediate used in the synthesis of antidepressants, antiviral drugs, anti-tuberculosis medications like isoniazid, and the gout treatment drug topiroxostat

Organic Synthesis Reagent

A building block used for the preparation of isonicotinic acid and 4-dimethylaminopyridine (DMAP)

Agrochemical Intermediate

A key structural unit used in the development of pesticides and herbicides

Specialty Chemical Precursor

A precursor used in the manufacturing of specialty dyes, functional polymers, and catalyst ligands

  1. isonicotinonitril-
  2. 4-Cyanopiperidine
  3. 4-Dimethylaminopyridine
  4. C6H4N2
  5. AC1L1OWY

4-Cyanopyridine (4-cp) FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

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GHS classification*

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