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4-Cyanopyridine (CAS No: 100-48-1) plays a vital role in the global heterocyclic chemistry market, primarily serving as the essential precursor for Isoniazid, a critical first-line antibiotic for treating tuberculosis. Because Isoniazid is included on the World Health Organization’s List of Essential Medicines, demand for this intermediate remains exceptionally stable regardless of economic cycles. Beyond its pharmaceutical applications, 4-Cyanopyridine is increasingly sought after in the U.S. fine chemicals sector for synthesizing 4-Dimethylaminopyridine (DMAP)—a powerful organocatalyst required for complex acylation reactions—and as a key building block for modern gout treatments like Topiroxostat. The supply chain for this chemical is specialized, as it is produced as a byproduct of 3-cyanopyridine ammoxidation; consequently, its market availability and pricing are closely tied to the demand for Vitamin B3, particularly within major manufacturing centers in India and China. As a premier 4-Cyanopyridine (4-CP) supplier offering 98% purity, we provide American companies with a reliable supply, consistent quality, and comprehensive documentation, including CoA and TDS for all grades. Our services extend beyond distribution to support the full product lifecycle, including route scouting, process development, analytical method development, and scaling up to commercial manufacturing. We also provide expert assistance with GMP-compliant quality assurance, regulatory filings, and international logistics coordination.
4-Cyanopyridine (CAS No: 100-48-1) plays a vital role in the global heterocyclic chemistry market, primarily serving as the essential precursor for Isoniazid, a critical first-line antibiotic for treating tuberculosis. Because Isoniazid is included on the World Health Organization’s List of Essential Medicines, demand for this intermediate remains exceptionally stable regardless of economic cycles. Beyond its pharmaceutical applications, 4-Cyanopyridine is increasingly sought after in the U.S. fine chemicals sector for synthesizing 4-Dimethylaminopyridine (DMAP)—a powerful organocatalyst required for complex acylation reactions—and as a key building block for modern gout treatments like Topi...
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Pharmaceutical, Elemental Derivatives
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Pharmaceutical Actives & Precursors, Pyridine
Intermediates & Precursors, Aminopyridines & Functionalized Pyridines
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Chemical Properties & Specifications
H302 (94.9%): Harmful if swallowed
H312 (58.2%): Harmful in contact with skin
H319 (43%): Causes serious eye irritation
H332 (58.2%): Harmful if inhaled
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P321, P330, P337+P317, P362+P364, and P501
Key Intermediate in the synthesis of a variety of drugs. The nitrile (-CN) group is readily hydrolyzed to a carboxylic acid (-COOH) or reduced to an amine (-CH2NH2)
Precursor for the synthesis of complex pyridine derivatives, including the powerful nucleophilic catalyst 4-Dimethylaminopyridine (DMAP)
Intermediate in the development of certain pesticides and herbicides that incorporate the pyridine ring structure.
An important fine chemical intermediate used in the synthesis of antidepressants, antiviral drugs, anti-tuberculosis medications like isoniazid, and the gout treatment drug topiroxostat
A building block used for the preparation of isonicotinic acid and 4-dimethylaminopyridine (DMAP)
A key structural unit used in the development of pesticides and herbicides
A precursor used in the manufacturing of specialty dyes, functional polymers, and catalyst ligands
No. 4-Cyanopyridine is classified as a highly critical Pharmaceutical Intermediate or a Heterocyclic Building Block, but it is not an Active Pharmaceutical Ingredient.
Main use is the synthesis of Isoniazid (INH), a crucial anti-tuberculosis agent, and the highly selective organocatalyst DMAP (4- Dimethylaminopyridine).
Isoniazid (INH) (Anti-Tuberculosis drug), Topiroxostat (Gout medication), Fampridine (Multiple Sclerosis drug), and various HDAC inhibitors.
DMAP (Catalyst), specialty dyes, and agrochemicals.
Various Agro actives and their related intermediates.
4-Cyanopyridine (4-CP), also known as Isonicotinonitrile, is a critical heterocyclic building block used as an intermediate in the synthesis of pharmaceuticals like Isoniazid, Topiroxostat, and Bromazepam, as well as agrochemicals and catalysts like DMAP
This compound is widely used in the pharmaceutical, agrochemical, and fine chemical industries for the production of medicines, pesticides, and specialty reagents
It is soluble in water, alcohols, ethanol, ether, and benzene, and is typically used in organic synthesis and catalytic protocols
Standard specifications include CAS number 100-48-1, high purity (typically >=99%), and available documentation such as COA, TDS, impurity reports, and regulatory compliance documents
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Intermediates & Precursors
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