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4,6-Dichloropyrimidine is a high-value symmetric heterocyclic intermediate essential for the synthesis of diverse bioactive molecules in the pharmaceutical and agrochemical industries. As a chlorinated pyrimidine derivative, it features two highly reactive chlorine atoms at the 4 & 6 positions, which serve as excellent leaving groups for nucleophilic aromatic substitution (SNAr) reactions. The electron-deficient nature of the pyrimidine ring makes 4,6-DCP particularly effective for sequential functionalization. Chemists selectively replace one or both chlorine atoms with various nucleophiles such as amines, alkoxides, or thiols to create complex chemical scaffolds. This Capability makes it a cornerstone in CDMO workflows for drug discovery and scale-up. In the life sciences sector, 4,6-DCP is a primary precursor for several blockbuster active ingredients. Its symmetric structure allows for the streamlined synthesis of pyrimidine-based compounds used in oncology and inflammatory disease treatments. We are the leading pharmaceutical intermediate Supplier and agro chemical intermediate producer worldwide, ensuring comprehensive regulatory support & CoA traceability for various grades with global supply capability with reliable lead time.
4,6-Dichloropyrimidine is a high-value symmetric heterocyclic intermediate essential for the synthesis of diverse bioactive molecules in the pharmaceutical and agrochemical industries. As a chlorinated pyrimidine derivative, it features two highly reactive chlorine atoms at the 4 & 6 positions, which serve as excellent leaving groups for nucleophilic aromatic substitution (SNAr) reactions. The electron-deficient nature of the pyrimidine ring makes 4,6-DCP particularly effective for sequential functionalization. Chemists selectively replace one or both chlorine atoms with various nucleophiles such as amines, alkoxides, or thiols to create complex chemical scaffolds. This Capability makes it a...
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Elemental Derivatives
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Pyridine
Halogenated Pyridines
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Chemical Properties & Specifications
H302+H312+H332 (52%): Harmful if swallowed, in contact with skin or if inhaled
H302 (61.6%): Harmful if swallowed
H312 (60.8%): Harmful in contact with skin
H314 (100%): Causes severe skin burns and eye damage
H317 (61.6%): May cause an allergic skin reaction
H318 (61.6%): Causes serious eye damage
H332 (60.8%): Harmful if inhaled
H335 (61.6%): May cause respiratory irritation
H400 (60.8%): Very toxic to aquatic life
H410 (61.6%): Very toxic to aquatic life with long lasting effects
Foundational building block for many tyrosine kinase inhibitors (TKIs) and other oncology-related APIs
To synthesize pyrimidine-based scaffolds for various therapeutic classes, including anti-hypertensives and anti-viral medications
Utilized in the multi-step synthesis of complex drugs where specific functional groups must be introduced at the 4 and 6 positions of the pyrimidine core.
Synthesis of highly effective fungicides, most notably Azoxystrobin, which is one of the world's best-selling agricultural fungicides Herbicides: Used as a precursor in the development of pyrimidinyl-based herbicides that target specific weed enzymatic pathways.
Precursor in the development of pyrimidinyl-based herbicides that target specific weed enzymatic pathways
Store in a cool, dry place. While stable at room temperature, keeping it in a climate-controlled environment prevents moisture-induced degradation
Like many halogenated heterocycles, it can be sensitive to prolonged moisture exposure. Store under an inert gas (e.g., Nitrogen) for long-term stability
laintain in original specialized plastic or glass-lined containers. Ensure containers re kept away from strong oxidizing agents and strong bases
4,6-DCP provides the central pyrimidine core for Azoxystrobin. Its two reactive chlorine sites allow for the attachment of the phenoxy and pyrimidinyloxy groups that are essential for the fungicide's biological activity.
Yes, depending on the reaction conditions and the strength of the nucleophile, both chlorines can be substituted simultaneously. However, chemists often use controlled conditions to replace them sequentially to create asymmetric molecules.
For most pharmaceutical and agrochemical syntheses, a minimum purity of 98–99% is required to ensure high yields and minimize unwanted byproducts in the downstream active ingredient.
