4,6-Dichloropyrimidine is a high-value symmetric heterocyclic intermediate essential for the synthesis of diverse bioactive molecules in the pharmaceutical and agrochemical industries. As a chlorinated pyrimidine derivative, it features two highly reactive chlorine atoms at the 4 & 6 positions, which serve as excellent leaving groups for nucleophilic aromatic substitution (SNAr) reactions. The electron-deficient nature of the pyrimidine ring makes 4,6-DCP particularly effective for sequential functionalization. Chemists selectively replace one or both chlorine atoms with various nucleophiles such as amines, alkoxides, or thiols to create complex chemical scaffolds. This Capability makes it a cornerstone in CDMO workflows for drug discovery and scale-up. In the life sciences sector, 4,6-DCP is a primary precursor for several blockbuster active ingredients. Its symmetric structure allows for the streamlined synthesis of pyrimidine-based compounds used in oncology and inflammatory disease treatments. We are the leading pharmaceutical intermediate Supplier and agro chemical intermediate producer worldwide, ensuring comprehensive regulatory support & CoA traceability for various grades with global supply capability with reliable lead time.
4,6-Dichloropyrimidine is a high-value symmetric heterocyclic intermediate essential for the synthesis of diverse bioactive molecules in the pharmaceutical and agrochemical industries. As a chlorinated pyrimidine derivative, it features two highly reactive chlorine atoms at the 4 & 6 positions, which serve as excellent leaving groups for nucleophilic aromatic substitution (SNAr) reactions. The electron-deficient nature of the pyrimidine ring makes 4,6-DCP particularly effective for sequential functionalization. Chemists selectively replace one or both chlorine atoms with various nucleophiles such as amines, alkoxides, or thiols to create complex chemical scaffolds. This Capability makes it a cornerstone in CDMO workflows for drug discovery and scale-up. In the life sciences sector, 4,6-DCP is a primary precursor for several blockbuster active ingredients. Its symmetric structure allows for the streamlined synthesis of pyrimidine-based compounds used in oncology and inflammatory disease treatments. We are the leading pharmaceutical intermediate Supplier and agro chemical intermediate producer worldwide, ensuring comprehensive regulatory support & CoA traceability for various grades with global supply capability with reliable lead time.
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PharmaceuticalAgrochemicalsElemental Derivatives
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Pharmaceutical Actives & PrecursorsAgrochemical IntermediatesPyridine
Intermediates & PrecursorsHalogenated Heterocycles
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Chemical Properties & Specifications
Foundational building block for many tyrosine kinase inhibitors (TKIs) and other oncology-related APIs
To synthesize pyrimidine-based scaffolds for various therapeutic classes, including anti-hypertensives and anti-viral medications
Utilized in the multi-step synthesis of complex drugs where specific functional groups must be introduced at the 4 and 6 positions of the pyrimidine core.
Synthesis of highly effective fungicides, most notably Azoxystrobin, which is one of the world's best-selling agricultural fungicides Herbicides: Used as a precursor in the development of pyrimidinyl-based herbicides that target specific weed enzymatic pathways.
Precursor in the development of pyrimidinyl-based herbicides that target specific weed enzymatic pathways
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