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4,6 Dichloropyrimidine

4,6 Dichloropyrimidine

CAS Number: 1193-21-1

Molecular Formula: C4H2Cl2N2

Agrochemical SynthesisAzoxystrobin PrecursorPyrimidine Building BlockHeterocyclic Nucleophilic SubstitutiorKinase Inhibitor ScaffoldTechnical Grade DichloropyrimidineAPI: Abacavir l Ticagrelor l DasatinibSulfa Drugs (Sulfonamide Antimicrobials) Portfolio

About 4,6 Dichloropyrimidine

4,6-Dichloropyrimidine (CAS No. 1193-21-1) is increasingly utilized by North American pharmaceutical houses as a pivotal heterocyclic building block in the API intermediates market, where its high-reactivity chlorinated structure is essential for custom synthesis services targeting novel antiviral and oncology therapeu...

Synonyms

  • null
  • 4,6-dichlorpyrimidin
  • zlchem 225
  • Pyrimidine,6-dichloro-
  • 4,6-dichlorpyrimidine;
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4,6 Dichloropyrimidine Specifications

CAS Number
1193-21-1
Molecular Formula
C4H2Cl2N2
Molecular Weight
148.98 g/mol
IUPAC Name
4,6-dichloropyrimidine
Canonical SMILES
C1=C(N=CN=C1Cl)Cl
InChI Key
XJPZKYIHCLDXST-UHFFFAOYSA-N
InChI
1S/C4H2Cl2N2/c5-3-1-4(6)8-2-7-3/h1-2H
PubChem CID
70943
EINECS Number
214-770-2
HSN No
29335990
Molecular Weight
148.98 g/mol
Melting Point
65-67 °C (lit.)
Boiling Point
176ºC at 760mmHg
Freezing point
66°C
GHS Hazard Statements
H302+H312+H332 (52%): Harmful if swallowed, in contact with skin or if inhaled H302 (61.6%): Harmful if swallowed H312 (60.8%): Harmful in contact with skin H314 (100%): Causes severe skin burns and eye damage H317 (61.6%): May cause an allergic skin reaction H318 (61.6%): Causes serious eye damage H332 (60.8%): Harmful if inhaled H335 (61.6%): May cause respiratory irritation H400 (60.8%): Very toxic to aquatic life H410 (61.6%): Very toxic to aquatic life with long lasting effects
Precautionary Statement Codes
P260, P261, P264, P270, P271, P272, P273, P280, P301+P317, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P310, P316, P317, P319, P321, P330, P333+P317, P362+P364, P363, P391, P403+P233, P405, and P501
Hazard Classes and Categories
Acute Tox. 4 (100%), Skin Corr. 1B (100%), Skin Sens. 1 (100%), Eye Dam. 1 (100%), STOT SE 3 (100%), Aquatic Chronic 1 (100%)

Kinase Inhibitors

Foundational building block for many tyrosine kinase inhibitors (TKIs) and other oncology-related APIs

Antiviral & Cardiovascular Agents

A synthesis of pyrimidine-based scaffold for various therapeutic classes, including anti-hypertensives and anti-viral medications

Sequential Substitution

A first fold for multi-step synthesis of complex drugs where specific functional groups must be introduced at the 4 and 6 positions of the pyrimidine core.

Strobilurin Fungicides

A Primary Target: Azoxystrobin (CAS No: 131860-33-8) – Broad-Spectrum Strobilurin Fungicide. A highly effective fungicide synthesis, most notably Azoxystrobin, which is one of the world's best-selling agricultural fungicides

Herbicides

A precursor in the development of pyrimidinyl-based herbicides that target specific weed enzymatic pathways

Pharmaceutical Development

A key intermediate in the synthesis of various pharmaceuticals, particularly antiviral and anticancer agents

Agricultural Chemicals

An essential intermediate used in the formulation of herbicides and pesticides

Material Science

A compound employed in the production of specialty polymers, resins, dyes, and pigments

Biochemical Research

A versatile building block utilized in the synthesis of nucleoside analogs for studying cellular processes

Abacavir API Precursor Portfolio

A Primary Target: Abacavir Sulphate (CAS No: 188062-50-2) Anti-HIV Reverse Transcriptase Inhibitor

Ticagrelor API Precursor Portfolio

A Primary Target: Ticagrelor (CAS No: 274693-27-5) Reversible P2Y₁₂ Platelet Aggregation Inhibitor / Blood Thinner

Dasatinib API Precursor Portfolio

A Primary Target: Dasatinib (CAS No: 302962-49-8) Multi-kinase / BCR-ABL & Src Tyrosine Kinase Inhibitor for CML Oncology

Sulfa Drugs (Sulfonamide Antimicrobials) Portfolio

A Primary Target: Sulfamethoxazole, Sulfadiazine, and Sulfamethazine APIs – Antibacterial / Antimicrobial Agents.

  1. null
  2. 4,6-dichlorpyrimidin
  3. zlchem 225
  4. Pyrimidine,6-dichloro-
  5. 4,6-dichlorpyrimidine;

4,6 Dichloropyrimidine FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

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