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3-(2-Chloro-4-pyrimidi nyl)-1-methyl-1H-indole

3-(2-Chloro-4-pyrimidi nyl)-1-methyl-1H-indole

CAS Number: 1032452-86-0

Molecular Formula: C13H10ClN3

About 3-(2-Chloro-4-pyrimidi nyl)-1-methyl-1H-indole

3-(2-Chloro-4-pyrimidinyl)-1-methyl-1H-indole (CAS 1032452-86-0) is an essential building block in the synthesis of oncology therapeutics, particularly serving as a key precursor for third-generation EGFR inhibitors like Osimertinib, with US-based bulk chemical suppliers now prioritizing 99% purity to meet stringent FD...

3-(2-Chloro-4-pyrimidi nyl)-1-methyl-1H-indole Specifications

CAS Number

1032452-86-0

Molecular Formula

C13H10ClN3

Molecular Weight

243.69 g/mol

IUPAC Name

3-(2-chloropyrimidin-4-yl)-1-methylindole

Canonical SMILES

CN1C=C(C2=CC=CC=C12)C3=NC(Cl)=NC=C3

InChI Key

IIBWXYHPBMUNJP-UHFFFAOYSA-N

CAS Number

1032452-86-0

Molecular Formula

C13H10ClN3

Molecular Weight

243.69 g/mol

IUPAC Name

3-(2-chloropyrimidin-4-yl)-1-methylindole

Canonical SMILES

CN1C=C(C2=CC=CC=C12)C3=NC(Cl)=NC=C3

InChI Key

IIBWXYHPBMUNJP-UHFFFAOYSA-N

Molecular Weight

243.69 g/mol

Physical appearance

Yellow Solid

Pharmaceutical Intermediate

A key building block and critical organic intermediate utilized in the synthesis of the third-generation EGFR tyrosine kinase inhibitor Osimertinib (Tagrisso) for the treatment of non-small cell lung cancer

Organic Synthesis Building Block

A functionalized heterocyclic compound used in laboratory research and development for the construction of complex bioactive molecules, particularly those involving indole and pyrimidine scaffolds

Antineoplastic Research Tool

A specialized chemical reagent employed in medicinal chemistry and pharmaceutical science for the development and production of targeted anticancer therapies.

3-(2-Chloro-4-pyrimidi nyl)-1-methyl-1H-indole FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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