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2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone (CAS 32384-65-9) is a vital silyl-protected intermediate in the US API intermediates market, primarily utilized for the stereoselective synthesis of SGLT2 inhibitors and other C-glycoside pharmaceuticals where Pharma/API purity 99% is required to maintain strictly controlled glycosylation pathways. The 2,3,4,6-Tetrakis-O-(trimethylsilyl)-D-gluconic acid delta-lactone serves as a high purity fine chemical essential for advanced carbohydrate chemistry applications, seeing increased demand from US-based CDMOs who are expanding custom synthesis services to support domestic drug development and localized production of metabolic therapeutics. D-Gluconic acid, 2,3,4,6-tetrakis-O-(trimethylsilyl)-, delta-lactone is increasingly sourced by leading bulk chemical supplier networks in North America as research and manufacturing facilities shift toward more robust, moisture-sensitive reagents that comply with American Chemical Society standards for general industry purity 98% in specialized organic synthesis. We are an established 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone intermediates supplier with >= 99% purity in the united states, ensuring minimal carry-over of impurities in the final API, and a broad range of various pharmaceutical intermediates for API manufacturers and finished formulators, providing comprehensive analytical (HPLC/NMR/MS) and supporting 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone COA/TDS/SDS region-specific regulatory support. reliable lead times, worldwide supply chain capabilities
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone (CAS 32384-65-9) is a vital silyl-protected intermediate in the US API intermediates market, primarily utilized for the stereoselective synthesis of SGLT2 inhibitors and other C-glycoside pharmaceuticals where Pharma/API purity 99% is required to maintain strictly controlled glycosylation pathways. The 2,3,4,6-Tetrakis-O-(trimethylsilyl)-D-gluconic acid delta-lactone serves as a high purity fine chemical essential for advanced carbohydrate chemistry applications, seeing increased demand from US-based CDMOs who are expanding custom synthesis services to support domestic drug development and localized production of metabolic therapeutics. D-Gl...
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Intermediates & Precursors
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Chemical Properties & Specifications
P273, P391, and P501
Aquatic Chronic 1 (100%)
Highly stable, silyl-protected precursor that allows for regiospecific reactions at the anomeric centre without interfering with the secondary hydroxyl groups
Serves as a high-purity volatile derivative for GC-MS sugar profiling, ensuring precise pharmaceutical QC/QA in complex carbohydrate characterisation.
Building block for the synthesis of Dapagliflozin, ensuring a streamlined pathway from D-Gluconolactone to the final bioactive molecule
High-purity reference material for the validation of chromatographic methods in carbohydrate research
Functions as a key electrophilic building block, where silyl protecting groups prevent unwanted side reactions at secondary hydroxyl sites during nucleophilic attack
Provides a robust TMS-protected matrix that facilitates purification and handling in large-scale API manufacturing environments
A key building block and silylated derivative of D-gluconolactone primarily used as a precursor in the industrial synthesis of sodium-glucose cotransporter 2 (SGLT2) inhibitors, including dapagliflozin, canagliflozin, and empagliflozin, for the management of type 2 diabetes
A protected sugar derivative employed in glycoscience and carbohydrate research for regioselective and chemoselective manipulations, such as the synthesis of trans-cyclohexane-bearing C-glucose and other complex biomolecules
A high-purity reference material utilized in research laboratories and quality control for the calibration of analytical instruments and the validation of chromatographic and mass spectrometry methods.
Our high-purity 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone (Dapagliflozin Stage-3) is a benchmark product in our carbohydrate synthesis portfolio. As a specialized CDMO partner, we provide this derivatized lactone to facilitate the complex C-glycosylation steps required for SGLT2 inhibitor production.
In the SGLT2 synthesis pathway, any trace moisture will cause the trimethylsilyl (TMS) groups to deprotect prematurely. This leads to polymerization and significant yield loss during the C-glycosylation step. By delivering a vacuum-distilled product with ultra-low KF moisture, we provide the Technical Authority required for high-efficiency API scale-up, reducing the "Total Cost of Quality" for the innovator.
Many CDMOs struggle with de-bromination during the conversion of the ketone to the methylene bridge. Our team uses selective reduction chemistry that specifically targets the carbonyl group while leaving the C-Br and C-Cl bonds untouched. This level of chemical market intelligence allows us to provide a precursor that preserves the vital halogen functionalities required for the final coupling steps.
For commercial volumes, we offer a 10–12 week lead time, including full analytical validation (NMR, HPLC, GC-MS). As an experienced CDMO, we maintain a dedicated pilot plant to support the rapid transition from R&D quantities to metric-ton supply, ensuring your clinical and commercial timelines are never compromised.
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone is a silylated derivative of D-gluconolactone primarily used as a key intermediate in the synthesis of sodium-glucose cotransporter 2 (SGLT2) inhibitors, such as Dapagliflozin, Canagliflozin, and Empagliflozin, for treating type 2 diabetes
This compound is widely used in the pharmaceutical and fine chemical industries for the development of antidiabetic agents and in analytical chemistry for carbohydrate derivatization
It is a moisture-sensitive liquid typically handled under inert gas and is compatible with organic solvents used in liquid-phase chemical synthesis
Standard specifications include CAS number 32384-65-9, purity ≥98% by GC, and documentation such as COA, TDS, impurity reports, and regulatory compliance documents
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a generally accepted MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Intermediates & Precursors
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