16-ALFA-HYDROXY- PREDNISOLONE (16-HPN)

CAS Number: 13951-70-7

Molecular Formula: C21H28O6

About 16-ALFA-HYDROXY- PREDNISOLONE (16-HPN)

16-alpha-Hydroxy Prednisolone (CAS 13951-70-7) serves as a critical 11-beta-hydroxysteroid specialized for the synthesis of high-potency inhaled corticosteroids like budesonide and ciclesonide, with the United States market seeing a significant shift toward custom synthesis services to optimize metabolic stability and ...

16-ALFA-HYDROXY- PREDNISOLONE (16-HPN) Specifications

CAS Number

13951-70-7

Molecular Formula

C21H28O6

Molecular Weight

376.44 g/mol

IUPAC Name

(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

Canonical SMILES

C[C@]12C[C@@H]([C@H]3[C@H]\([C@@H]1C[C@H]\([C@@]2\(C\(=O\)CO\)O\)O\)CCC4=CC\(=O\)C=C[C@]34C)O

InChI Key

SEKYBDYVXDAYPY-ILNISADRSA-N

PubChem CID

11047056.0

CAS Number

13951-70-7

Molecular Formula

C21H28O6

Molecular Weight

376.44 g/mol

IUPAC Name

(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

Canonical SMILES

C[C@]12C[C@@H]([C@H]3[C@H]\([C@@H]1C[C@H]\([C@@]2\(C\(=O\)CO\)O\)O\)CCC4=CC\(=O\)C=C[C@]34C)O

InChI Key

SEKYBDYVXDAYPY-ILNISADRSA-N

PubChem CID

11047056.0

Molecular Weight

376.44 g/mol

Physical appearance

White to off-white crystalline powder

Pharmaceutical Intermediate

An important medicinal chemistry building block and precursor used in the synthesis of glucocorticoids and anti-inflammatory drugs like budesonide and ciclesonide

Anti-inflammatory Agent

A highly effective corticosteroid derivative utilized in research for treating intractable asthma and central nervous system disorders

Pharmaceutical Analytical Impurity

A critical reference material used as an analytical standard for the quality control and impurity profiling of active pharmaceutical ingredients such as budesonide and desonide

Xenobiotic Metabolite

A functionalized steroid derivative employed in metabolic studies to investigate the bioconversion and cytochrome P450 enzymatic pathways in human liver microsomes.