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1-Bromo-4-fluorobenzene (CAS NO : 460-00-4)

1-Bromo-4-fluorobenzene (CAS No: 460-00-4) is a critical bifunctional aromatic building block, increasingly utilized by American specialty chemical manufacturers in palladium-catalyzed cross-coupling protocols, such as Suzuki-Miyaura and Heck reactions, to synthesize complex molecular architectures. This mixed aryl halide serves as an essential intermediate in the development of novel medicinal chemistry frameworks, particularly for the synthesis of atypical antipsychotic agents and other halogenated active pharmaceutical ingredients (APIs). Furthermore, its strategic application as a precursor for the fungicide flusilazole and various agrochemical derivatives highlights its vital role in enhancing crop protection efficacy through precise molecular functionalization. As a globally established 1-Bromo-4-fluorobenzene supplier with 99% purity, we ensure a dependable supply, consistent quality, and complete regulatory documentation, including 1-Bromo-4-fluorobenzene CoA and TDS across all grades. Beyond supply, we support partners through the entire product lifecycle from route scouting, process and formulation development, and analytical method development to scale-up, process optimization, and pilot-to-commercial manufacturing. Our teams also assist with GMP-compliant quality assurance, regulatory documentation, and global supply chain and logistics coordination.

1-Bromo-4-fluorobenzene
1-Bromo-4-fluorobenzene

1-Bromo-4-fluorobenzene (CAS No: 460-00-4) is a critical bifunctional aromatic building block, increasingly utilized by American specialty chemical manufacturers in palladium-catalyzed cross-coupling protocols, such as Suzuki-Miyaura and Heck reactions, to synthesize complex molecular architectures. This mixed aryl halide serves as an essential intermediate in the development of novel medicinal chemistry frameworks, particularly for the synthesis of atypical antipsychotic agents and other halogenated active pharmaceutical ingredients (APIs). Furthermore, its strategic application as a precursor for the fungicide flusilazole and various agrochemical derivatives highlights its vital role in en...

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Industry

Elemental Derivatives

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Category

Bromine

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Sub-category

Bromo Aromatics & Cyclic Derivatives

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Chemical Properties & Specifications

Applications of 1-Bromo-4-fluorobenzene

Pharmaceutical Intermediate

A halogenated intermediate for the synthesis of active pharmaceutical ingredients such as atypical antipsychotic agents, antidepressants like Escitalopram, and blood glucose regulators like Canagliflozin

Agrochemical Intermediate

An intermediate in the synthesis of herbicides, pesticides, and fungicides, including the pesticide Flusilazole

Organic Synthesis Reagent

A standard substrate for palladium-catalyzed cross-coupling reactions such as Suzuki, Heck, and Sonogashira coupling to produce substituted aromatic compounds

Analytical Standard

A tuning, internal, or surrogate standard for gas chromatography/mass spectrometry in the determination of volatile organic compounds

Have Questions About 1-Bromo-4-fluorobenzene?
We've Got Answers.

1-Bromo-4-fluorobenzene is a dihalogenated benzene derivative used as a key intermediate in the synthesis of pharmaceuticals, such as atypical antipsychotic agents and breast cancer treatments, and agrochemicals

This compound is widely utilized in the pharmaceutical, agrochemical, and specialty chemical industries for organic synthesis and the production of fine chemicals

It is a colorless to pale yellow liquid that is soluble in organic solvents and slightly soluble in water

Standard specifications include CAS number 460-00-4, high purity (typically >98%), and availability of documentation such as COA, TDS, impurity reports, and regulatory compliance documents

Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time

The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.

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