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Etoricoxib

Etoricoxib

CAS Number: 202409-33-4

Molecular Formula: C18H15ClN2O2S

Purity: 99.6% w/w

Therapeutic category : NSAIDEffective inhibition of COX-2 enzymeGrade: IP

About Etoricoxib

Etoricoxib API (CAS 202409-33-4) is a selective COX-2 inhibitor widely used in pharmaceutical manufacturing for anti-inflammatory and analgesic formulations. Known for its targeted mechanism of action, it inhibits cyclooxygenase-2 to reduce pain and inflammation while maintaining a favorable gastrointestinal profile co...

Synonyms

  • Arcoxia
  • etoricoxib
  • L 791456
  • L-791456
  • L791456
View all

Etoricoxib Specifications

CAS Number
202409-33-4
Molecular Formula
C18H15ClN2O2S
Molecular Weight
358.78 g/mol
IUPAC Name
5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
Canonical SMILES
CC1=NC=C(C=C1)C2=C(C=C(C=N2)Cl)C3=CC=C(C=C3)S(=O)(=O)C
InChI Key
MNJVRJDLRVPLFE-UHFFFAOYSA-N
InChI
1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3
PubChem CID
123619
EINECS Number
600-932-4
MDL Number
MFCD00972245
UNSPSC Code
51101506
eClass
38080190
NACRES
NA.24
HSN No
3004.90.99
Molecular Weight
358.78 g/mol
Melting Point
205-207°C
Flash Point
210°C (Predicted)
Etoricoxib Assay / Etoricoxib Purity
99.6% w/w
Solubility
Soluble in acetone, ethanol, methanol, chloroform and Dichloromethane.
Sulphated ash
0.09% w/w
Purity
99.5
Acetic acid
Not detected
Dimethyl formamide
Not detected
Hazard Statements Code
H302, H315, H319, H335
Precautionary Statements Code
P264, P270, P301 + P312, P305 + P351 + P338
GHS Classification Code
Category 2, 3, 2A, 4
Hazard Classification
Health Hazards: Harmful by ingestion, may cause respiratory irritation, skin, and eye irritation
Water Hazard Class
WGK 2 (Class 2: hazardous to water)

Solid Oral Dosage Formulations

Etoricoxib API is widely used in the development and manufacturing of tablets for anti-inflammatory and analgesic therapies, supporting formulation teams working on stable, high-bioavailability oral dosage forms.

Pharmaceutical Formulation Development & Scale-Up

Used by formulation scientists and CDMOs during process optimization, bioequivalence studies, and scale-up manufacturing, where consistent impurity profiles and particle size distribution are critical.

Contract Development & Manufacturing (CDMO)

Etoricoxib API is sourced by contract manufacturers supporting global pharmaceutical programs, enabling efficient batch production, process validation, and commercial manufacturing workflows.

Combination Drug Development

Utilized in the development of combination therapies with other analgesics or supportive APIs, where selective COX-2 inhibition is required alongside complementary mechanisms of action.

Stability Studies & Regulatory Documentation

Applied in stability testing, analytical method development, and dossier preparation, where reproducibility, documentation (DMF/COA), and compliance with ICH guidelines are essential for regulatory submissions.

Temperature

Store at 20–25°C (68–77°F)

Environment

Keep in a cool, dry place away from light and moisture

Protection

Use airtight containers to prevent contamination and degradation

Storage Class Code

13 - Non-combustible solids

COA
Download
MSDS
Download
  1. Arcoxia
  2. etoricoxib
  3. L 791456
  4. L-791456
  5. L791456

Etoricoxib FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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