1-(6-Methyl-3-pyridinyl)-2-(4-methyl sulfonyl) phenyl ethanone (keto Sulfone) (CAS NO : 221615-75-4)

1-(6-Methyl-3-pyridinyl)-2-(4-methylsulfonyl)phenyl ethanone, commonly known as Keto Sulfone, is a synthetic intermediate and impurity associated with the production of Etoricoxib, a selective COX-2 inhibitor. It is used in pharmaceutical quality control to ensure drug purity and compliance with regulatory standards.

Industries

Pharmaceutical

Sub-category

Active Pharmaceutical Ingredients (APIs)

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Chemical Properties & Specifications

Applications of 1-(6-Methyl-3-pyridinyl)-2-(4-methyl sulfonyl) phenyl ethanone (keto Sulfone)

Pharmaceutical Industry

Used as an impurity reference standard in the manufacturing and quality control of Etoricoxib API and finished formulations.

Analytical Laboratories

Employed in the validation of HPLC and other analytical methods for impurity profiling.

Research & Development

Used in drug discovery and impurity profiling studies related to COX-2 inhibitors and anti-inflammatory compounds.

Have Questions About 1-(6-Methyl-3-pyridinyl)-2-(4-methyl sulfonyl) phenyl ethanone (keto Sulfone)?
We've Got Answers.

What is the primary application of 1-(6-Methyl-3-pyridinyl)-2-(4-methylsulfonyl)phenyl ethanone in the pharmaceutical industry?

It is used as an impurity reference standard for the quality control of Etoricoxib, ensuring compliance with pharmacopeial standards and regulatory requirements.

How does Keto Sulfone contribute to the quality assurance of Etoricoxib products?

It allows pharmaceutical companies to identify and quantify impurities, ensuring the purity, safety, and efficacy of Etoricoxib drug products during manufacturing and stability testing.

What are the recommended analytical techniques for detecting this compound in formulations?

High-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), and gas chromatography-mass spectrometry (GC-MS) are commonly used for the detection and quantification of this impurity.

Is 1-(6-Methyl-3-pyridinyl)-2-(4-methylsulfonyl)phenyl ethanone stable under standard storage conditions?

Yes, it is stable when stored in a cool, dry place away from light and moisture. Proper storage ensures long-term stability for accurate analytical testing.