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1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone, commonly referred to as DFTA, is an intermediate in the synthesis of Fluconazole and other azole-based antifungal medications. It is used in pharmaceutical manufacturing and research & development as part of the chemical pathway to producing COX-2 inhibitors and related therapeutic agents.
1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone, commonly referred to as DFTA, is an intermediate in the synthesis of Fluconazole and other azole-based antifungal medications. It is used in pharmaceutical manufacturing and research & development as part of the chemical pathway to producing COX-2 inhibitors and related therapeutic agents.
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Intermediates & Precursors
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Chemical Properties & Specifications
Eye Contact: Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention. Skin Contact: Wash off immediately with plenty of water for at least 15 minutes. Get medical attention immediately if symptoms occur. Inhalation: Remove to fresh air. Get medical attention immediately if symptoms occur. Ingestion: Clean mouth with water and drink afterwards plenty of water. Get medical attention if symptoms occur.
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.
Personal Precautions Ensure adequate ventilation. Use personal protective equipment asrequired. Avoid dust formation. Environmental Precautions Should not be released into the environment. See Section 12 for additional Ecological Information. Methods for Containment and Clean Sweep up and shovel into suitable containers for disposal. Avoid dust formation.
Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Products Carbon monoxide (CO), Carbon dioxide (CO2), Nitrogen oxides (NOx), Hydrogen fluoride
Used as an intermediate in the synthesis of Fluconazole and related compounds.
Employed in the development of triazole-based antifungal agents and other bioactive molecules.
Wear personal protective equipment/face protection. Ensure adequate ventilation. Avoid contact with skin, eyes or clothing. Avoid ingestion and inhalation. Avoid dust formation.
Keep containers tightly closed in a dry, cool and well-ventilated place
Available in various laboratory-scale quantities for synthesis and analysis
DFTA is an intermediate used in the synthesis of Fluconazole and other azole-based antifungal medications. It is an essential compound in the production of COX-2 inhibitors and other therapeutic agents.
It acts as a precursor in the synthesis of Fluconazole, providing a triazole ring system that is integral to the bioactive structure of the drug, a potent antifungal agent.
Yes, it should be handled with care. Use appropriate PPE (personal protective equipment) including gloves, goggles, and lab coats to avoid skin and eye contact. Follow standard laboratory safety protocols when working with this compound.
High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) are commonly used for detecting and quantifying DFTA in pharmaceutical formulations and ensuring the purity of Fluconazole.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Intermediates & Precursors
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