Domperidone Maleate is a selective dopamine D2 receptor antagonist used in treating gastrointestinal motility disorders and nausea. Unlike centrally acting agents, it does not significantly cross the blood–brain barrier, making it preferred in patients sensitive to extrapyramidal side effects. It’s formulated as an API in solid oral dosage forms and suspensions. Stable Salt Form: Maleate version is preferred for improved solubility and oral bioavailability.
Domperidone Maleate is a selective dopamine D2 receptor antagonist used in treating gastrointestinal motility disorders and nausea. Unlike centrally acting agents, it does not significantly cross the blood–brain barrier, making it preferred in patients sensitive to extrapyramidal side effects. It’s formulated as an API in solid oral dosage forms and suspensions. Stable Salt Form: Maleate version is preferred for improved solubility and oral bioavailability.
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Active Pharmaceutical Ingredients (APIs)
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Chemical Properties & Specifications
Not classified as hazardous
QT prolongation risk in high doses — avoid in cardiac patients without ECG monitoring
Use PPE, avoid inhalation or contact with skin/eyes
Used in the treatment of delayed gastric emptying, GERD, and functional dyspepsia.
Indicated for prevention and treatment of nausea and vomiting caused by gastrointestinal disorders or chemotherapy.
Sometimes used off-label to increase prolactin levels for postpartum lactation support.
Store in tightly sealed container, away from light and moisture
1 kg / 5 kg / 25 kg HDPE drums with double liner
3–5 years under controlled room temperature
CAS No. : 563-41-7
Category : Pharmaceutical Actives & Precursors
Sub-Category : Intermediates & Precursors
Description: Semicarbazide Hydrochloride is a pharmaceutical intermediate used primarily in the synthesis of hydr...
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