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Tromethamine

Tromethamine

CAS Number: 77-86-1

Molecular Formula: C4H11NO3

About Tromethamine

Tromethamine (CAS No: 77-86-1) serves as a critical aliphatic aminotriol buffering agent featuring a unique primary amine and tri-hydroxy functionality, which delivers exceptional buffering capacity in the physiological pH range (7.0 to 9.0) and optimal ionic stability for complex biological systems. In the global B2B ...

Synonyms

  • Tri(hydroxymethyl)aminomethane
  • Tris Buffer
  • Tris(hydroxymethyl)aminomethane
  • Tris-Magnesium(II)-Potassium Chloride Buffer
  • Tris-Mg(II)-KCl Buffer
View all

Tromethamine Specifications

CAS Number
77-86-1
Molecular Formula
C4H11NO3
IUPAC Name
2-amino-2-(hydroxymethyl)propane-1,3-diol
Canonical SMILES
C(C(CO)(CO)N)O
InChI Key
LENZDBCJOHFCAS-UHFFFAOYSA-N
InChI
InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
HSN No
29221990
melting_point
171-172 °C
boiling_point
219-220 °C at 10 mm Hg
solubility
79.1 mg/mL in ethylene glycol; 26 mg/mL in methanol; 14.6 mg/mL in anhyd ethanol; 22 mg/mL in 95% ethanol; 14 mg/mL in dimethyl formamide; 20 mg/mL in acetone; 0.5 mg/mL in ethyl acetate; 0.4 mg/mL in olive oil; 0.1 mg/mL in cyclohexane; 0.05 mg/mL in chloroform; less than 0.05 mg/mL in carbon tetrachloride
Precautionary Statement Codes
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Hazard Classes and Categories
Skin Irrit. 2 (81.4%) Skin Sens. 1 (82.9%)

Pharmaceuticals

An active buffering agent and counterion used to manage metabolic acidosis and formulate pharmaceutical drugs

Cosmetics Industry

A pH regulator, emulsifier, and stabilizer used in skincare and personal care products to reduce irritation

Biotechnology and Research

An effective buffering component used in biological experiments, molecular biology, and PCR testing

Industrial Applications

A versatile dispersant and additive used in coatings, cleaning solutions, and rubber processing

  1. Tri(hydroxymethyl)aminomethane
  2. Tris Buffer
  3. Tris(hydroxymethyl)aminomethane
  4. Tris-Magnesium(II)-Potassium Chloride Buffer
  5. Tris-Mg(II)-KCl Buffer

Tromethamine FAQs

Minimum Order Quantity

25 kg (pilot) · 1 MT (commercial)

Lead Time

3 – 5 weeks ex-works

Incoterms

FOB · CIF

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

Regional Availability

India · EU · Middle East · Southeast Asia

Documentation

SDS · COA · TDS available on request

Compliance & Quality

REACH registered*

GHS/SDS available

ISO 9001:2015 site*

RoHS compliant*

Global sourcing network

Consistent quality & reliability

End-to-end technical support

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