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Triethyl orthopropionate serves as a broad-spectrum pharmaceutical intermediate used in the synthesis of several specialised APIs. 1,1,1-Triethoxypropane (CAS 115-80-0) serves as a critical building block in the API intermediates market, where its role in Claisen rearrangement reactions facilitates the synthesis of complex pharmaceutical molecules with 99% purity for high-precision medicinal chemistry. Orthopropionic acid triethyl ester is increasingly favoured by CDMOs providing custom synthesis services due to the growing demand for high-purity fine chemicals that ensure stringent regulatory compliance in the production of cardiovascular and anti-inflammatory drugs. Ethyl orthopropionate is also a vital component for a bulk chemical supplier catering to the flavour and fragrance industry, where a 98% purity grade is utilised to achieve specific organoleptic profiles, reflecting a global sourcing shift toward reliable, high-specification technical intermediates. We are a globally established Triethyl orthopropionate intermediates supplier with >= 99% purity, ensuring minimal carry-over of impurities in the final TEOP API, and a broad range of various pharmaceutical intermediates for API manufacturers and finished formulators, providing comprehensive analytical (HPLC/NMR/MS) and supporting Triethyl orthopropionate COA/TDS/SDS region-specific regulatory support, reliable lead times, and worldwide supply chain capabilities.
Triethyl orthopropionate serves as a broad-spectrum pharmaceutical intermediate used in the synthesis of several specialised APIs. 1,1,1-Triethoxypropane (CAS 115-80-0) serves as a critical building block in the API intermediates market, where its role in Claisen rearrangement reactions facilitates the synthesis of complex pharmaceutical molecules with 99% purity for high-precision medicinal chemistry. Orthopropionic acid triethyl ester is increasingly favoured by CDMOs providing custom synthesis services due to the growing demand for high-purity fine chemicals that ensure stringent regulatory compliance in the production of cardiovascular and anti-inflammatory drugs. Ethyl orthopropionate i...
Chemical Properties & Specifications
Flam. Liq. 3 (98.7%) & Acute Tox. 4 (54.5%)
Skin Irrit. 2 (75.3%) & Eye Irrit. 2A (81.8%)
A versatile orthoester primarily used in the Claisen rearrangement to construct new C-C bonds and synthesize gamma,delta-unsaturated esters
An essential building block utilized as a starting material for the synthesis of active pharmaceutical ingredients and medicinal compounds
A specialty chemical used to provide fruity notes in the formulation of perfumes and food flavorings
A functionalised building block employed in the production of speciality polymers, dyes, and pigments
An effective medium for chemical processes and a water-trapping agent used to enhance the stability of coatings and adhesives
This compound is widely utilized in the pharmaceutical, agrochemical, flavor and fragrance, polymer, and chemical manufacturing industries
Colorless liquid soluble in alcohol, ether, chloroform, and ethyl acetate, though it is moisture-sensitive and hydrolyzes slowly in water
Standard specifications include CAS number 115-80-0 specification, a Triethyl orthopropionate assay of typically ≥96% or ≥99%, and availability of documentation such as COA, TDS, impurity reports, and regulatory compliance documents
Triethyl orthopropionate serves as a broad-spectrum pharmaceutical intermediate used primarily in the synthesis of several specialized APIs, including anti-malarial and rheumatological treatments like Chloroquine and Hydroxychloroquine, where it is deployed to build critical core side-chains. Additionally, it acts as a foundational structural building block for the topical corticosteroid anti-inflammatory hormone Modrasone (Alclometasone dipropionate), and it functions more broadly as a specialized protecting reagent or reactant to form cyclic orthoester intermediates that hydrolyze into active 17,21-dipropionate ester linkages on the complex ring structures of various Steroidal and Adrenal Cortex Hormones (such as Beclomethasone dipropionate).
While all three function as excellent alkylating and protecting reagents, the choice depends entirely on the required carbon chain length they introduce: TEOF (Triethyl orthoformate) adds a single carbon (-CH=) formyl or methine group, TEOA (Triethyl orthoacetate) introduces a two-carbon methyl-substituted (-C(CH₃) =) group, and TEOP (Triethyl orthopropionate) introduces a longer three-carbon ethyl-substituted (-C(CH₂CH₃) =) group. This specific structural difference means TEOP is uniquely selected when a target pharmaceutical or fragrance molecule specifically demands a propionate or ethyl side-chain modification rather than a formyl or acetate group.
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
TEOP is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and Triethyl orthopropionate specific grade.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Active Pharmaceutical Ingredients (APIs)
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