Tosylmethyl isocyanide, also known as TosMIC, is a reagent used extensively in organic chemistry for the introduction of nitrile groups into molecules. It is particularly important in heterocyclic synthesis and diastereoselective reactions. TosMIC is widely employed in reactions such as the Van Leusen reaction, which forms nitriles from ketones, and for the synthesis of various biologically active compounds.
Tosylmethyl isocyanide, also known as TosMIC, is a reagent used extensively in organic chemistry for the introduction of nitrile groups into molecules. It is particularly important in heterocyclic synthesis and diastereoselective reactions. TosMIC is widely employed in reactions such as the Van Leusen reaction, which forms nitriles from ketones, and for the synthesis of various biologically active compounds.
.3d8f8f41.svg)
Pharmaceutical
.3556d45a.svg)
Pharmaceutical Actives & Precursors
Intermediates & Precursors
Included in Quote
Included in Quote
Included in Quote
Included in Quote
.7767eb0f.png&w=3840&q=75){kind=small}
Chemical Properties & Specifications
H302: Harmful if swallowed. H319: Causes serious eye irritation. H317: May cause an allergic skin reaction.
P264: Wash hands thoroughly after handling. P270: Do not eat, drink, or smoke when using this product. P280: Wear protective gloves/eye protection/face protection. P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
TosMIC reacts with ketones to form nitriles, allowing the introduction of a one-carbon unit into a molecular structure. It is particularly useful in organic synthesis.
TosMIC is employed in the synthesis of heterocyclic compounds, such as pyrroles and imidazoles, which are often used as biologically active molecules in pharmaceuticals.
Used in diastereoselective reactions with sugar-derived aldehydes, TosMIC aids in the synthesis of diastereomerically pure products.
Store in a cool, dry, well-ventilated area, away from moisture and heat sources. Keep the container tightly closed when not in use.
Available in various packaging sizes; contact Scimplify for specific packaging details.
![3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]-phenol, monohydrochloride](/_next/image?url=https%3A%2F%2Fcdn.scimplify.com%2Fproducts%2Fimages%2F66dadf1c5a536b2739932a85%2Fe573d280-4a1f-48fe-ad33-bc5044d3fc1b.png&w=256&q=75)
CAS No. : 175591-09-0
Category : Pharmaceutical Actives & Precursors
Sub-Category : Intermediates & Precursors
Description: This compound is a key intermediate in the synthesis of Venlafaxine, an antidepressant in the seroto...
![Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-
oxoperidin-1-yl) phenyl)-4,5,6,7-
tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-
carboxylate](/_next/static/media/placeholder.300ac90c.svg)
