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Tosylmethyl isocyanide, also known as TosMIC, is a reagent used extensively in organic chemistry for the introduction of nitrile groups into molecules. It is particularly important in heterocyclic synthesis and diastereoselective reactions. TosMIC is widely employed in reactions such as the Van Leusen reaction, which forms nitriles from ketones, and for the synthesis of various biologically active compounds.
Tosylmethyl isocyanide, also known as TosMIC, is a reagent used extensively in organic chemistry for the introduction of nitrile groups into molecules. It is particularly important in heterocyclic synthesis and diastereoselective reactions. TosMIC is widely employed in reactions such as the Van Leusen reaction, which forms nitriles from ketones, and for the synthesis of various biologically active compounds.
Chemical Properties & Specifications
H302: Harmful if swallowed. H319: Causes serious eye irritation. H317: May cause an allergic skin reaction.
P264: Wash hands thoroughly after handling. P270: Do not eat, drink, or smoke when using this product. P280: Wear protective gloves/eye protection/face protection. P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
TosMIC reacts with ketones to form nitriles, allowing the introduction of a one-carbon unit into a molecular structure. It is particularly useful in organic synthesis.
TosMIC is employed in the synthesis of heterocyclic compounds, such as pyrroles and imidazoles, which are often used as biologically active molecules in pharmaceuticals.
Used in diastereoselective reactions with sugar-derived aldehydes, TosMIC aids in the synthesis of diastereomerically pure products.
Store in a cool, dry, well-ventilated area, away from moisture and heat sources. Keep the container tightly closed when not in use.
Available in various packaging sizes; contact Scimplify for specific packaging details.
TosMIC is primarily used as a reagent in organic synthesis to introduce nitrile groups into molecules, especially in the synthesis of heterocyclic compounds and in the Van Leusen reaction for the formation of nitriles.
In the Van Leusen reaction, TosMIC reacts with ketones to form nitriles, allowing the introduction of a one-carbon unit into the target molecule, enabling the synthesis of complex organic structures.
TosMIC should be handled with care, and appropriate personal protective equipment (PPE) should be used, including gloves, goggles, and lab coats, to prevent skin and eye contact.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Intermediates & Precursors
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