Tenofovir Alafenamide Fumarate

CAS Number: 1392275-56-7

Molecular Formula: C46H62N12O14P2

Purity: Tenofovir Alafenamide Fumarate 98% purity

About Tenofovir Alafenamide Fumarate

Tenofovir Alafenamide Fumarate (CAS 202138-50-9) serves as a critical nucleoside reverse transcriptase inhibitor in the global API intermediates market, where its enhanced lymphatic delivery and reduced systemic toxicity compared to earlier prodrugs have made it a cornerstone in modern antiviral regimens for HIV-1 and ...

Synonyms

GS-7340
GS-734003
L-alanine, N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-, 1-methylethyl ester
tenofovir alafenamide
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Tenofovir Alafenamide Fumarate Specifications

CAS Number

1392275-56-7

Molecular Formula

C46H62N12O14P2

Molecular Weight

592.54 g/mol

IUPAC Name

(E)-but-2-enedioic acid;propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate

Canonical SMILES

CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3.CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3.C(=CC(=O)O)C(=O)O

InChI Key

SVUJNSGGPUCLQZ-FQQAACOVSA-N

InChI

InChI=1S/2C21H29N6O5P.C4H4O4/c2*1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27;5-3(6)1-2-4(7)8/h2*5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24);1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*15-,16+,33+;/m11./s1

HSN No

29335990

CAS Number

1392275-56-7

Molecular Formula

C46H62N12O14P2

Molecular Weight

592.54 g/mol

IUPAC Name

(E)-but-2-enedioic acid;propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate

Canonical SMILES

CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3.CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3.C(=CC(=O)O)C(=O)O

InChI Key

SVUJNSGGPUCLQZ-FQQAACOVSA-N

InChI

HSN No

29335990

Molecular Weight

592.54 g/mol

Purity

Tenofovir Alafenamide Fumarate 98% purity

Antiviral Agent

A potent nucleoside reverse transcriptase inhibitor (NRTI) used as a primary active pharmaceutical ingredient in the treatment of chronic hepatitis B virus (HBV) infection and as a core component of antiretroviral therapy (ART) regimens for HIV-1 infection

Pharmaceutical Intermediate

A high-purity crystalline building block utilized in the synthesis of specialized prodrugs and combination antiviral therapies

HIV and HBV Reverse Transcriptase Inhibitor

A bioactive small molecule employed in scientific research and clinical studies to inhibit viral replication by blocking the reverse transcriptase enzyme

Organic Synthesis Building Block

A functionalized phosphonamidate derivative used in medicinal chemistry for the development of targeted drug delivery systems and lipophilic prodrugs.

GS-7340
GS-734003
L-alanine, N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-, 1-methylethyl ester
tenofovir alafenamide
vemlidy