Montelukast intermediate (2-[1-(Mercaptomethyl)cyclopropyl] acetic acid)

Montelukast intermediate (2-[1-(Mercaptomethyl)cyclopropyl] acetic acid)

CAS Number
162515-68-6
Molecular Formula
C6H10O2S
Precursor for Montelukast

About Montelukast intermediate (2-[1-(Mercaptomethyl)cyclopropyl] acetic acid)

1-(Mercaptomethyl)cyclopropaneacetic acid is a key intermediate in the synthesis of Montelukast, a leukotriene receptor antagonist used for the treatment of asthma and allergic rhinitis. This compound features a cyclopropane ring with a mercaptomethyl group, playing a crucial role in building the active pharmaceutical ...

Montelukast intermediate (2-[1-(Mercaptomethyl)cyclopropyl] acetic acid) Specifications

CAS Number
162515-68-6
Molecular Formula
C6H10O2S
Molecular Weight
146.21 g/mol
IUPAC NameORBotanical Name
2-[1-(sulfanylmethyl)cyclopropyl]acetic acid
Canonical SMILES
C1C(C1CS)CC(=O)O
InChI Key
VFAXPOVKNPTBTM-UHFFFAOYSA-N
InChI
1S/C6H10O2S/c7-5(8)3-6(4-9)1-2-6/h9H,1-4H2,(H,7,8) / 1S/C6H10O2S/c7-6(8)3-4-1-5(4)2-9/h4-5,9H,1-3H2,(H,
EINECS Number
420-240-3
MDL Number
MFCD03411600
UNSPSC Code
12352100
eClass
39021701
NACRES
NA.22
Molecular Weight
146.21 g/mol
Appearance
Off-white solid
Odor
42–45 °C
Boiling Point
290.1 ± 13.0 °C (Predicted)
Density
1.228 ± 0.06 g/cm³ (Predicted)
Condition to Avoid
Air Sensitive,Heat Sensitive
Shelf Life
2 years
GHS Classification
Corrosive to metals: Category 1 Acute toxicity (Oral, Dermal): Category 4 Skin corrosion: Category 1B Skin sensitization: Category 1 Hazardous to the aquatic environment (Chronic): Category 2
Hazard Identification
Acute oral toxicity-Category 4 Acute dermal toxicity-Category 4 Skin Corrosion/Irritation-Category 1 B Serious Eye Damage/Eye Irritation-Category 1 Skin Sensitization-Category 1 Specific target organ toxicity (single exposure)-Category 3 Target Organs - Respiratory system.
Precautionary Statements
P234: Keep only in original packaging. P260: Do not breathe dust/fume/gas/mist/vapors/spray. P264: Wash hands thoroughly after handling. P270: Do not eat, drink, or smoke when using this product. P272: Contaminated work clothing should not be allowed out of the workplace. P273: Avoid release to the environment. P280: Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331+P310: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Immediately call a POISON CENTER/doctor. P303+P361+P353+P310+P363: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. Immediately call a POISON CENTER/doctor. Wash contaminated clothing before reuse. P304+P340+P310: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305+P351+P338+P310: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. Immediately call a POISON CENTER/doctor. P390: Absorb spillage to prevent material damage. P391: Collect spillage. P405: Store locked up. P406: Store in a corrosion-resistant container with a resistant inner liner. P501: Dispose of contents/container in accordance with local/regional/national/international regulations.

Pharmaceutical Manufacturing

Serves as a crucial intermediate in the synthesis of Montelukast, aiding in the production of medications for asthma and allergic rhinitis.

Agricultural Chemistry

It is utilized in the synthesis of certain pesticides and fungicides, contributing to crop protection by targeting specific plant pathogens.​

Biochemical Research

Researchers employ this compound to study cyclopropyl-containing molecules, aiding in the development of new therapeutic agents with unique mechanisms of action.

Temperature

Store at room temperature (typically 15–30°C or 59–86°F).

Environment

Keep in a dry, well-ventilated area away from moisture and incompatible substances.

Protection

Store in original, tightly sealed containers to prevent oxidation and degradation.

Packaging Options

Available in 1 kg, 5 kg, 10 kg, and 25 kg containers. Custom packaging available upon request.

Montelukast intermediate (2-[1-(Mercaptomethyl)cyclopropyl] acetic acid) FAQs

Minimum Order Quantity

25 kg (pilot) · 1 MT (commercial)

Lead Time

3 – 5 weeks ex-works

Incoterms

FOB · CIF

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

Regional Availability

India · EU · Middle East · Southeast Asia

Documentation

SDS · COA · TDS available on request

Compliance & Quality

REACH registered*

GHS/SDS available

ISO 9001:2015 site*

RoHS compliant*

Global sourcing network

Consistent quality & reliability

End-to-end technical support

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