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2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one, commonly known as IT-7, is an intermediate compound in the synthesis of Itraconazole, an antifungal medication. IT-7 plays a crucial role in the pharmaceutical manufacturing process of Itraconazole, contributing to its efficacy in treating fungal infections.
![Itraconazole (IT7) (2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one)](/_next/image?url=https%3A%2F%2Fcdn.scimplify.com%2Fproducts%2Fimages%2F670ccc8008d93fd3b357e73f%2Ff3532649-4237-4ca1-b064-9d7ad3581810.png&w=3840&q=75)
2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one, commonly known as IT-7, is an intermediate compound in the synthesis of Itraconazole, an antifungal medication. IT-7 plays a crucial role in the pharmaceutical manufacturing process of Itraconazole, contributing to its efficacy in treating fungal infections.
Chemical Properties & Specifications
H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.
P261 Avoid breathing dust/fume/gas/mist/vapors/spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P302+P352 IF ON SKIN: Wash with plenty of soap and water. P304+P340 IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a poison center or doctor if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P337+P313 If eye irritation persists: Get medical advice/attention. P362 Take off contaminated clothing and wash before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked
Serves as a key intermediate in the production of Itraconazole, facilitating the construction of its complex triazole ring structure.
Utilized in the development of antifungal agents, aiding in the study of triazole derivatives and their biological activities.
Store in a tightly-closed container when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from sources of ignition.
Store at -20°C in a cool, dry, well-ventilated area, away from heat and moisture.
Available in various quantities; contact Scimplify for specific packaging details.
IT-7 is primarily used as a pharmaceutical intermediate in the synthesis of Itraconazole, a widely used antifungal medication. It plays a crucial role in the chemical synthesis of triazole compounds, including the development of Itraconazole.
IT-7 is used as an intermediate compound to facilitate the creation of the triazole ring structure in the production of Itraconazole, helping to form the molecular scaffold for the active pharmaceutical ingredient.
When handled with appropriate safety precautions, IT-7 is safe to use in chemical research and pharmaceutical synthesis. Protective equipment such as gloves, goggles, and lab coats should be worn to avoid skin or eye contact.
IT-7 remains stable for several years if stored under controlled conditions (cool, dry, and away from heat and moisture), ensuring it maintains its effectiveness for pharmaceutical applications.
