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O,O-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate (CAS 94790-37-1) represents a cornerstone in the API intermediates market, serving as a high-performance peptide coupling reagent essential for the synthesis of complex macrocyclic pharmaceuticals where high purity fine chemicals (Pharma/API purity 99% | General Industry purity 98%) are required to prevent racemization. HBTU acts as a critical facilitator for CDMOs engaging in custom synthesis services, as the current shift toward strategic global sourcing demands reagents that provide rapid reaction kinetics and high yield efficiency across diverse amino acid sequences. 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate is increasingly favored by bulk chemical supplier networks due to its superior stability and solubility profiles, reflecting a growing industry trend toward automated solid-phase peptide synthesis (SPPS) that requires stringent regulatory and analytical validation (Pharma/API purity 99% | General Industry purity 98%). We are an globally established HBTU intermediates supplier with >= 99% purity, ensuring minimal carry-over of impurities in the final API, and a broad range of various pharmaceutical intermediates for API manufacturers and finished formulators, providing comprehensive analytical (HPLC/NMR/MS) and supporting HBTU COA/TDS/SDS region-specific regulatory support. reliable lead times, worldwide supply chain capabilities
O,O-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate (CAS 94790-37-1) represents a cornerstone in the API intermediates market, serving as a high-performance peptide coupling reagent essential for the synthesis of complex macrocyclic pharmaceuticals where high purity fine chemicals (Pharma/API purity 99% | General Industry purity 98%) are required to prevent racemization. HBTU acts as a critical facilitator for CDMOs engaging in custom synthesis services, as the current shift toward strategic global sourcing demands reagents that provide rapid reaction kinetics and high yield efficiency across diverse amino acid sequences. 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium ...
Chemical Properties & Specifications
P210, P240, P241, P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P332+P313, P337+P313, P362, P370+P378, P403+P233, P405, and P501
Skin Irrit. 2 (100%)
Eye Irrit. 2A (100%)
A widely utilized uronium salt reagent primarily used for the activation of free carboxylic acids to facilitate efficient amide bond formation in both solid-phase and solution-phase peptide synthesis
A versatile coupling agent employed in the construction of complex molecules, including natural products, macrocycles, and pharmaceutical intermediates through the formation of amide and ester linkages
A functional reagent used to facilitate the conjugation of carboxylic acid-containing molecules to amine-bearing biomolecules such as proteins, antibodies, and oligonucleotides
A critical component in the one-pot synthesis of acyl azides, ureas, and carbamates, as well as in the construction of sulfoguanidine analogs and metal-organic complexes.
HBTU, also known as 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, is a premier coupling reagent primarily used in solid-phase and solution-phase peptide synthesis to activate carboxylic acids for amide bond formation
This reagent is widely used in the pharmaceutical, biotechnology, and agrochemical industries, as well as in academic research for drug development and biochemical studies
It is soluble in organic solvents such as DMF and DMSO and is compatible with standard Fmoc-based solid-phase peptide synthesis protocols
Standard specifications include CAS number 94790-37-1, high purity (typically ≥98% or ≥99% by HPLC), and availability of documentation such as COA, TDS, impurity reports, and regulatory compliance documents
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Active Pharmaceutical Ingredients (APIs)
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