Glimepiride

CAS Number: 93479-97-1

Molecular Formula: C24H34N4O5S

Glimepiride manufacturersbuy Glimepiride APIGlimepiride bulk supplierantidiabetic pharmaceutical gradeGlimepiride USP BP EPindustrial grade sulfonylurea chemicals

About Glimepiride

Glimepiride (CAS 93479-97-1) is a predominant second-generation sulfonylurea in the API intermediates market, essential for formulating oral solid dosage treatments for Type 2 diabetes. As a leading bulk chemical supplier, we recognize that CDMOs are increasingly focusing on high-purity fine chemicals (Pharma/API purit...

Glimepiride Specifications

CAS Number

93479-97-1

Molecular Formula

C24H34N4O5S

Molecular Weight

490.62 g/mol

IUPAC Name

3-ethyl-4-methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-methylcyclohexyl]carbamoyl}amino)sulfonyl]phenyl}ethyl)-2,5-dihydro-1H-pyrrole-1-carboxamide

Canonical SMILES

COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC

InChI Key

WIGIZIANZCJQQY-RUCARUNLSA-N

InChI

InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19-

PubChem CID

3476

EINECS Number

642-221-0

MDL Number

MFCD00878417

HSN No

30049099

CAS Number

93479-97-1

Molecular Formula

C24H34N4O5S

Molecular Weight

490.62 g/mol

IUPAC Name

3-ethyl-4-methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-methylcyclohexyl]carbamoyl}amino)sulfonyl]phenyl}ethyl)-2,5-dihydro-1H-pyrrole-1-carboxamide

Canonical SMILES

COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC

InChI Key

WIGIZIANZCJQQY-RUCARUNLSA-N

InChI

InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19-

PubChem CID

3476

EINECS Number

642-221-0

MDL Number

MFCD00878417

HSN No

30049099

Molecular Weight

490.62 g/mol

Melting Point

207°C

Boiling Point

677.0±65.0 °C at 760 mmHg

Density

1.29±0.1 g/cm3

pKa

7.26

PSA

130 Å²

logP

3.9

Average mass

490.62 g/mol

Monoisotopic mass

490.22499137 Da

Molar mass

490.62 g/mol

Vapour pressure

0.0±2.2 mmHg at 25°C

Precautionary Statement Codes

P201, P202, P261, P264, P270, P271, P280, P281, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P311, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501

Hazard Classes and Categories

Acute Tox. 3 (37.5%) Eye Irrit. 2 (62.5%)

Type 2 Diabetes Mellitus Management

Glimepiride is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes by stimulating pancreatic beta cells to release insulin and increasing peripheral insulin sensitivity

Pharmaceutical Research and Development

This second-generation sulfonylurea is used in clinical studies and comparative trials to evaluate glycemic efficacy, cardiovascular safety, and its role as a second-line therapy in combination with metformin or insulin

Biochemical and Pharmacological Assays

Glimepiride serves as a research tool to study ATPase-dependent potassium channel blocking in pancreatic cells and to investigate extrapancreatic effects such as GLUT4 transport protein activation in fat and muscle tissues