Fexo 2 or 2-Methyl-2-Phenyl Propyl Acetate, an intermediate in the multi-step synthesis of Fexofenadine HCl, a widely used non-sedating antihistamine, is a compound of unique properties. Often referred to in synthesis protocols as a “Fexo Chloro” derivative, it forms the side chain structure leading to the final API. Its structural backbone facilitates alkylation and acylation steps during late-stage intermediate development. It plays a structural role in building the side-chain scaffold of the antihistamine API. It is a Stage 5 intermediate in the “Fexo Chloro” synthesis pathway.
Fexo 2 or 2-Methyl-2-Phenyl Propyl Acetate, an intermediate in the multi-step synthesis of Fexofenadine HCl, a widely used non-sedating antihistamine, is a compound of unique properties. Often referred to in synthesis protocols as a “Fexo Chloro” derivative, it forms the side chain structure leading to the final API. Its structural backbone facilitates alkylation and acylation steps during late-stage intermediate development. It plays a structural role in building the side-chain scaffold of the antihistamine API. It is a Stage 5 intermediate in the “Fexo Chloro” synthesis pathway.
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Intermediates & Precursors
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Chemical Properties & Specifications
Not classified as hazardous under standard use
P280: Wear gloves and eye protection during handling P403: Store in well-ventilated location P501: Dispose contents according to local regulations
*Serves as an intermediate in the multi-step synthesis of Fexofenadine hydrochloride (Fexo HCl) *Commonly referred to as a Stage 5 intermediate in “Fexo Chloro” manufacturing routes *Functions as a building block during alkylation and acylation reactions to form the side chain *Used in regulated API plants with traceable batch data
*Adds warmth and fruity-floral body to muguet, musk, tropical, and lactonic accords *Compatible with soaps, fine fragrance, hair care, and fabric care bases *Typical dosage: 0.05–1% depending on formulation
Fexofenadine Synthesis: Used by API and intermediate manufacturers as a structurally critical reactant in the production of non-sedating antihistamines. Ensures structural uniformity and batch consistency when forming downstream coupling reagents and side-chain intermediates.
Used in long-retention body sprays, powdery fragrances, and as a fixative base in floral-fruity applications.
15–30°C; protect from air and light
5 kg, 25 kg, 50 kg HDPE or aluminum containers
24 months sealed
Non-hazardous
Stable under ambient pharma and F&F conditions
