Fexo 2 (2-Methyl-2-Phenyl Propyl Acetate)

Fexo 2 (2-Methyl-2-Phenyl Propyl Acetate)

CAS Number
18755-52-7
Molecular Formula
C12H16O2
Purity
92.3%
High-volume Fexo intermediate chainsDual-industry utilityREACH Pre-registeredISO 9001 Plant Intermediate

About Fexo 2 (2-Methyl-2-Phenyl Propyl Acetate)

Fexo 2 or 2-Methyl-2-Phenyl Propyl Acetate, an intermediate in the multi-step synthesis of Fexofenadine HCl, a widely used non-sedating antihistamine, is a compound of unique properties. Often referred to in synthesis protocols as a “Fexo Chloro” derivative, it forms the side chain structure leading to the final API. I...

Synonyms

  • 18755-52-7
  • neophyl acetate
  • (2-methyl-2-phenylpropyl) acetate
  • 2-METHYL-2-PHENYLPROPYL ACETATE
  • Benzeneethanol, b,b-dimethyl-, 1-acetate

Fexo 2 (2-Methyl-2-Phenyl Propyl Acetate) Specifications

CAS Number
18755-52-7
Molecular Formula
C12H16O2
IUPAC Name
(2-methyl-2-phenylpropyl) acetate
Canonical SMILES
CC(=O)OCC(C)(C)C1=CC=CC=C1
InChI Key
PEBXDRHRHPKKHS-UHFFFAOYSA-N
InChI
InChI=1S/C12H16O2/c1-10(13)14-9-12(2,3)11-7-5-4-6-8-11/h4-8H,9H2,1-3H3
EINECS Number
242-515-9
MDL Number
MFCD00009488
UNSPSC Code
12142000
HSN No
29153990
Appearance
Pale Yellow color liquid
Purity by GC
92.3%
Refractive Index
1.485–1.495
Solubility
Soluble in alcohols & organics; insoluble in water
GHS Classification
Not classified as hazardous under standard use
(P) Statements
P280: Wear gloves and eye protection during handling P403: Store in well-ventilated location P501: Dispose contents according to local regulations

Pharmaceutical Synthesis (Primary Use)

*Serves as an intermediate in the multi-step synthesis of Fexofenadine hydrochloride (Fexo HCl) *Commonly referred to as a Stage 5 intermediate in “Fexo Chloro” manufacturing routes *Functions as a building block during alkylation and acylation reactions to form the side chain *Used in regulated API plants with traceable batch data

Fragrance Use (Secondary Use)

*Adds warmth and fruity-floral body to muguet, musk, tropical, and lactonic accords *Compatible with soaps, fine fragrance, hair care, and fabric care bases *Typical dosage: 0.05–1% depending on formulation

Pharmaceutical End Use

Fexofenadine Synthesis: Used by API and intermediate manufacturers as a structurally critical reactant in the production of non-sedating antihistamines. Ensures structural uniformity and batch consistency when forming downstream coupling reagents and side-chain intermediates.

Fragrance End Use

Used in long-retention body sprays, powdery fragrances, and as a fixative base in floral-fruity applications.

Storage Conditions

15–30°C; protect from air and light

Packaging

5 kg, 25 kg, 50 kg HDPE or aluminum containers

Shelf Life

24 months sealed

Transport Classification

Non-hazardous

Stability

Stable under ambient pharma and F&F conditions

  1. 18755-52-7
  2. neophyl acetate
  3. (2-methyl-2-phenylpropyl) acetate
  4. 2-METHYL-2-PHENYLPROPYL ACETATE
  5. Benzeneethanol, b,b-dimethyl-, 1-acetate

Fexo 2 (2-Methyl-2-Phenyl Propyl Acetate) FAQs

Minimum Order Quantity

25 kg (pilot) · 1 MT (commercial)

Lead Time

3 – 5 weeks ex-works

Incoterms

FOB · CIF

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

Regional Availability

India · EU · Middle East · Southeast Asia

Documentation

SDS · COA · TDS available on request

Compliance & Quality

REACH registered*

GHS/SDS available

ISO 9001:2015 site*

RoHS compliant*

Global sourcing network

Consistent quality & reliability

End-to-end technical support

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