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(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one (CAS 163222-33-1) stands as a cornerstone in the API intermediates market, primarily utilized for the production of advanced lipid-lowering therapies that target the NPC1L1 transporter. As a leading bulk chemical supplier, we recognize that CDMOs are increasingly demanding high-purity fine chemicals (Pharma/API purity 99% | General Industry purity 98%) to ensure the precision of the final azetidinone structure and to mitigate the presence of enantiomeric impurities. SCH 58235 (CAS 163222-33-1) has seen significant global sourcing shifts toward manufacturers offering robust custom synthesis services that can accommodate complex multi-step organic synthesis and provide comprehensive impurity profiling to satisfy stringent regulatory compliance standards. Zetia (CAS 163222-33-1) remains a high-demand compound in the pharmaceutical sector, where maintaining strict adherence to cGMP and providing detailed analytical validation is essential for consistent reactivity in finished dosage form manufacturing. We are an established global API supplier offering >= 99% purity for semi-finished formulators, providing comprehensive analytical testing (HPLC/NMR/MS) and supporting documentation, including Ezetimibe COA, TDS, and SDS, along with region-specific regulatory support, reliable lead times, and worldwide supply chain capabilities.
(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one (CAS 163222-33-1) stands as a cornerstone in the API intermediates market, primarily utilized for the production of advanced lipid-lowering therapies that target the NPC1L1 transporter. As a leading bulk chemical supplier, we recognize that CDMOs are increasingly demanding high-purity fine chemicals (Pharma/API purity 99% | General Industry purity 98%) to ensure the precision of the final azetidinone structure and to mitigate the presence of enantiomeric impurities. SCH 58235 (CAS 163222-33-1) has seen significant global sourcing shifts toward manufacturers offering robust custom synthesi...
Chemical Properties & Specifications
P201, P202, P260, P264, P270, P271, P273, P280, P301+P312, P330, P302+P352, P304+P340, P305+P351+P338, P308+P313, P321, P314, P362+P364, P332+P313, P337+P313, P391, P403+P233, P405, and P501
Acute Tox. 4 (100%)
Skin Irrit. 2 (100%)
A selective cholesterol-lowering medication used as monotherapy or in combination with statins to inhibit the Niemann-Pick C1-Like 1 (NPC1L1) protein at the brush border of the small intestine, thereby reducing the absorption of dietary and biliary cholesterol for the management of primary hyperlipidemia, homozygous familial hypercholesterolemia, and homozygous sitosterolemia.
Ezetimibe is a selective cholesterol absorption inhibitor used to treat high blood cholesterol by reducing the amount of cholesterol absorbed from food in the small intestine
This compound is primarily used in the pharmaceutical and healthcare industries for the production of lipid-lowering medications
It is available as oral tablets, often as monotherapy or in fixed-dose combinations with statins, and is practically insoluble in water but soluble in methanol, ethanol, and acetone
Standard analytical specifications include CAS number 163222-33-1, high purity (typically >=99%), and documentation such as COA, TDS, impurity reports (monitoring for desfluoro ezetimibe), and regulatory compliance documents
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.
