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Ethynylmagnesium bromide (CAS 4301-14-8) serves as a vital organometallic reagent in the API intermediates market, facilitating the precise introduction of terminal alkyne groups through nucleophilic addition to carbonyl electrophiles to produce propargylic alcohols. As a premier bulk chemical supplier, we observe that global CDMOs are increasingly prioritizing high-purity fine chemicals (Pharma/API purity 99% | General Industry purity 98%) to streamline the synthesis of complex intermediates while adhering to rigorous regulatory compliance and anhydrous handling protocols. Ethynylmagnesium bromide (CAS 4301-14-8) is witnessing a surge in demand via custom synthesis services as strategic sourcing shifts emphasize the need for stabilized solutions that mitigate the risks of hazardous hydrolysis during large-scale manufacturing. This movement underscores the industry's reliance on high-performance building blocks that optimize yields in the total synthesis of oncology agents, such as (+)-4-demethoxydaunomycin, and other therapeutic classes requiring sophisticated carbon-carbon bond formation. Ethynylmagnesium bromide (CAS 4301-14-8) remains a cornerstone for constructing intricate molecular architectures, where maintaining a Pharma/API purity 99% | General Industry purity 98% profile is paramount for meeting the heightened purity standards of modern drug development and ensuring consistent reactivity in downstream transformations. We are an established global intermediates supplier with >= 99% purity, ensuring minimal carry-over of impurities in the final API. We offer a broad range of pharmaceutical intermediates for API manufacturers and finished formulators, providing comprehensive analytical support (HPLC/NMR/MS) and Ethynylmagnesium bromide COA/TDS/SDS documentation alongside region-specific regulatory support, reliable lead times, and worldwide supply chain capabilities.
Ethynylmagnesium bromide (CAS 4301-14-8) serves as a vital organometallic reagent in the API intermediates market, facilitating the precise introduction of terminal alkyne groups through nucleophilic addition to carbonyl electrophiles to produce propargylic alcohols. As a premier bulk chemical supplier, we observe that global CDMOs are increasingly prioritizing high-purity fine chemicals (Pharma/API purity 99% | General Industry purity 98%) to streamline the synthesis of complex intermediates while adhering to rigorous regulatory compliance and anhydrous handling protocols. Ethynylmagnesium bromide (CAS 4301-14-8) is witnessing a surge in demand via custom synthesis services as strategic sou...
Chemical Properties & Specifications
A cornerstone Grignard reagent used as a potent nucleophile for the introduction of ethynyl groups into various molecular scaffolds through 1,2-addition to aldehydes and ketones
A vital building block employed in the ethynylation of chiral aldehydes and the total synthesis of complex natural products like the antibiotic (+)-4-demethoxydaunomycin
A specialized reagent used to prepare alkyl(triethynyl)germanes and functionalized polymers for the development of materials with specific electronic or optical properties
A versatile intermediate used in the synthesis of ethynyl aziridines, unsaturated phosphonites, and anthracene-containing species for advanced organic frameworks.
Ethynylmagnesium Bromide is a highly reactive organometallic Grignard reagent primarily used in organic synthesis for carbon-carbon bond formation and the introduction of ethynyl groups into various molecular scaffolds
This compound is widely utilized in the pharmaceutical, agrochemical, material science, and chemical manufacturing industries for the production of complex organic molecules, natural products, and polymers
It is commonly supplied and used as a solution in anhydrous solvents such as tetrahydrofuran (THF) or diethyl ether and must be handled under inert atmospheres
Standard specifications include CAS number 4301-14-8, molar mass 129.24 g/mol, and availability of documentation such as COA, TDS, impurity reports, and regulatory compliance documents
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a generally accepted MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.
