

gamma-Valerolactone (CAS 108-29-2) is increasingly recognized in the US API intermediates market as a sustainable, bio-derived solvent and building block, particularly for the synthesis of complex pharmaceutical molecules where a Pharma/API purity 99% is required to ensure compliance with stringent FDA quality standards. 4-Methyl-gamma-butyrolactone serves as a high purity fine chemical for domestic CDMOs who are shifting away from traditional petroleum-based solvents toward greener alternatives to enhance supply chain resilience and meet ESG-driven regulatory compliance. GVL is also a pivotal component for the general industry at a purity of 98%, where its high boiling point and low toxicity make it an ideal candidate for custom synthesis services and as a precursor for specialty polymers and advanced biofuels. As an established gamma-Valerolactone suppliers in the united states, we ensure dependable supply, consistent quality, and complete regulatory documentation, including CoA and TDS across all grades. Beyond supply, we support partners through the entire product lifecycle from route scouting, process and formulation development, and analytical method development to scale-up, process optimisation, and pilot-to-commercial manufacturing. Our teams also assist with GMP-compliant quality assurance, regulatory documentation, and global supply chain and logistics coordination

gamma-Valerolactone (CAS 108-29-2) is increasingly recognized in the US API intermediates market as a sustainable, bio-derived solvent and building block, particularly for the synthesis of complex pharmaceutical molecules where a Pharma/API purity 99% is required to ensure compliance with stringent FDA quality standards. 4-Methyl-gamma-butyrolactone serves as a high purity fine chemical for domestic CDMOs who are shifting away from traditional petroleum-based solvents toward greener alternatives to enhance supply chain resilience and meet ESG-driven regulatory compliance. GVL is also a pivotal component for the general industry at a purity of 98%, where its high boiling point and low toxicit...
Industrial Chemicals
Organic Intermediates
Ketones & Solvents
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Chemical Properties & Specifications
P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P312, P303+P361+P353, P304+P340, P305+P351+P338, P321, P330, P362+P364, P337+P313, P370+P378, P403+P235, and P501
Flam. Liq. 2 (100%)
Acute Tox. 4 (100%)
A sustainable and non-toxic reaction medium used in organic synthesis, peptide chemistry, and biomass processing as an eco-friendly alternative to traditional dipolar aprotic solvents like DMF and NMP
A versatile building block and solvent utilized in the synthesis and formulation of active pharmaceutical ingredients and medicinal compounds
A biomass-derived component used to enhance the performance and efficiency of gasoline and biofuels while reducing carbon monoxide emissions
A platform molecule employed in the production of renewable polymers, resins, and value-added chemicals such as gamma-butyrolactone
A herbal-scented organic compound used as an additive in the perfume, cosmetic, and food industries.
γ-Valerolactone, or GVL, is a bio-based cyclic ester and platform chemical primarily used as a sustainable green solvent, fuel additive, and precursor for renewable polymers and liquid hydrocarbon fuels
This compound is widely used in the chemical manufacturing, pharmaceutical, energy, agrochemical, and fragrance industries for solvent replacement, biofuel production, and fine chemical synthesis
GVL is fully miscible with water, alcohols, and most organic solvents, and is stable under normal conditions, making it suitable for liquid-phase reactions and homogeneous catalysis
Standard specifications typically include high purity, a CAS number of 108-29-2, and technical documentation such as COA, TDS, impurity reports, and regulatory compliance documents
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.
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