

Trimethylsulfoxonium Iodide (CAS 1774-47-6) is a pivotal reagent in the North American API intermediates market, primarily serving as the precursor to dimethyloxosulfonium methylide for the Corey-Chaykovsky reaction used in the synthesis of epoxides and cyclopropanes. Trimethyloxosulfonium iodide is increasingly integrated into custom synthesis services within the United States, as domestic CDMOs prioritize high purity fine chemicals with a Pharma/API purity of 99% to ensure stringent regulatory compliance and minimize impurity profiles in downstream therapeutic candidates. Trimethylsulphoxonium iodide has seen a surge in demand from every major US-based bulk chemical supplier due to a strategic shift toward domestic sourcing and supply chain resilience, particularly for specialized applications in the development of semi-finished pharmaceutical formulations and advanced perovskite solar cell modifications. We are an established Trimethylsulfoxonium iodide intermediates supplier with >= 99% purity in the united states, ensuring minimal carry-over of impurities in the final API, and a broad range of various pharmaceutical intermediates for API manufacturers and finished formulators, providing comprehensive analytical (HPLC/NMR/MS) and supporting Trimethylsulfoxonium iodide COA/TDS/SDS region-specific regulatory support. reliable lead times, worldwide supply chain capabilities


Trimethylsulfoxonium Iodide (CAS 1774-47-6) is a pivotal reagent in the North American API intermediates market, primarily serving as the precursor to dimethyloxosulfonium methylide for the Corey-Chaykovsky reaction used in the synthesis of epoxides and cyclopropanes. Trimethyloxosulfonium iodide is increasingly integrated into custom synthesis services within the United States, as domestic CDMOs prioritize high purity fine chemicals with a Pharma/API purity of 99% to ensure stringent regulatory compliance and minimize impurity profiles in downstream therapeutic candidates. Trimethylsulphoxonium iodide has seen a surge in demand from every major US-based bulk chemical supplier due to a strat...
Industrial Chemicals
Organic Intermediates
Chlorinated Aromatic Compounds
.7767eb0f.png)

Chemical Properties & Specifications
P261, P264, P264+P265, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501
Acute Tox. 5 (17%)
Skin Irrit. 2 (61.7%)
Trimethylsulfoxonium Iodide is a crucial reagent in the Corey-Chaykovsky reaction used to prepare epoxide intermediates and cyclopropane derivatives, which are essential building blocks for complex pharmaceutical molecules and bioactive peptides
It serves as a powerful methylene-transfer and methylating agent, facilitating the introduction of methyl groups and the synthesis of sulfoxides and sulfones in academic and industrial laboratories
The compound is utilized in the production of agrochemicals, fine chemicals, and advanced materials like polymers to enhance thermal stability and chemical resistance.
Trimethylsulfoxonium Iodide is a sulfoxonium salt and organosulfur compound used primarily as a methylene-transfer reagent to prepare epoxides from ketones and aldehydes, and as a powerful methylating agent in organic synthesis
This compound is widely used in the pharmaceutical, agrochemical, biotechnology, and material science industries for drug development and chemical research
It is compatible with water, alcohols, and polar organic solvents, and is typically reacted with strong bases like sodium hydride to form reactive ylides
Standard specifications include CAS number 1774-47-6, purity ≥98%, molecular weight 220.07, and documentation such as COA, TDS, impurity reports, and regulatory compliance documents
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the specific shipping destination and order volume.
Category : Industrial Polymers
Sub-Category : Rosin-Based Resins & Binders
Description : Our Rosin Modified Phenolic Resins are high-performance complex polymers engineered through the cond...
Category : Industrial Polymers
Sub-Category : Rosin-Based Resins & Binders
Description : Our Rosin Modified Maleic Resins are high-melting thermoplastic resins engineered through the precis...