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Phosphorus Halide and Oxyhalide series-comprising Phosphorus Trichloride (PCl3), Phosphorus Oxychloride (POCl3), and Phosphorus Pentachloride (PCl5)- represents the foundational "workhorse" reagents for modern chemical synthesis. These compounds are indispensable for functional group transformations, particularly in the conversion of alcohols and carboxylic acids into their corresponding chlorides and esters. PCl3 serves as the primary precursor in the phosphorus value chain, essential for the production of plasticizers and organophosphorus pesticides. POCl3 (Phosphory| Chloride) is universally recognized for its role in the Vilsmeier-Haack reaction, enabling the formylation of electron-rich aromatics. PCls acts as a more aggressive chlorinating agent compared to its trivalent counterpart, frequently utilized for the synthesis of acid chlorides from carboxylic acids and for the conversion of amides to nitriles. High-purity grades of these reagents are critical for CDMO operations to ensure high yields and minimize side-product formation (such as phosphoric acid impurities). Due to their extreme sensitivity to moisture and the release of HCl gas upon hydrolysis, these products are handled under strict inert atmospheres (Nitrogen/Argon). We are the leading phosphorus derivatives supplier worldwide, ensuring comprehensive regulatory support & CoA traceability for various grades with global supply capability with reliable lead time.
Phosphorus Halide and Oxyhalide series-comprising Phosphorus Trichloride (PCl3), Phosphorus Oxychloride (POCl3), and Phosphorus Pentachloride (PCl5)- represents the foundational "workhorse" reagents for modern chemical synthesis. These compounds are indispensable for functional group transformations, particularly in the conversion of alcohols and carboxylic acids into their corresponding chlorides and esters. PCl3 serves as the primary precursor in the phosphorus value chain, essential for the production of plasticizers and organophosphorus pesticides. POCl3 (Phosphory| Chloride) is universally recognized for its role in the Vilsmeier-Haack reaction, enabling the formylation of electron-rich...
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Elemental Derivatives
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Phosphorus
Phosphorus Halides & Oxyhalides
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Chemical Properties & Specifications
Acute Toxicity (Inhalation): Category 2, Skin Corrosion/Irritation: Category 1, Serious Eye Damage/Eye Irritation: Category 1 Specific Target Organ Toxicity (Repeated Exposure): Category 2
H314: Causes severe skin burns and eye damage
H330: Fatal if inhaled H373: May cause damage to organs through prolonged or repeated exposure.
P260: Do not breathe dust/fume/gas/mist/vapours/spray
P280: Wear protective gloves/protective clothing/eye protection/face protection
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do; continue rinsing.
Chlorinating agent for converting alcohols and acids into chlorinated compounds.
Employed in the synthesis of various pharmaceutical intermediates.
Utilized in the production of pesticides and herbicides.
Involved in the manufacture of certain dyes and pigments.
Store in a cool, dry place at temperatures between 15–25°C (59–77°F)
Keep away from moisture, direct sunlight, and incompatible materials
Store in original, tightly sealed containers made of corrosion-resistant material.
Available in 1 kg, 5 kg, 10 kg, and 25 kg containers
It is used primarily as a chlorinating agent in organic synthesis, as well as in the production of pharmaceuticals, agrochemicals, dyes, and pigments.
It reacts violently with water, releasing heat and producing hydrochloric acid and phosphoric acid.
Use appropriate personal protective equipment (PPE), including gloves, protective clothing, and eye/face protection. Ensure adequate ventilation to avoid inhalation of dust or fumes.
Yes, it is classified as hazardous due to its corrosive nature and its ability to release toxic gases upon contact with moisture.
Store in a cool, dry, well-ventilated area, away from moisture and incompatible substances. Use corrosion-resistant packaging for safe storage.
