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Palladium (Pd), a soft, silvery-white metal and critical member of the Platinum Group Metals (PGM) family, is foundational to modern industrial chemistry, valued both as a precious metal asset & a peerless catalyst. In primary industrial form, Palladium 10% on Carbon (Pd/C) (CAS: 7440-05-3) is a heterogeneous supported catalyst where precisely 10% (w/w) of highly dispersed Pd nanoparticles are anchored onto an activated carbon matrix to maximise its reactive surface area. This formulation is indispensable across the Pharmaceutical (API synthesis) and Fine Chemical sectors due to its unique capacity to efficiently adsorb and activate molecular hydrogen (H₂), thereby driving vital transformations such as selective Hydrogenation (e.g., reduction of nitro groups to amines) and the critical Hydrogenolysis reaction used for the clean, selective cleavage of benzyl protecting groups. PALLIDIUM's heterogeneous nature simplifies post-reaction processing via filtration, which is a major benefit for process efficiency and the economical recovery and recycling of the precious metal. Due to the severe risk of pyrophoricity (spontaneous ignition) when dry, Pd/C' is a regulated UN3178 Flammable Solid and is therefore manufactured, shipped, and handled in a safe wetted state (typically 50 - 67% water content) to ensure compliance and safety across the supply chain by Palladium manufacturers. We are the leading Palladium supplier worldwide & a multiple-industry-specific Palladium grade producer, ensuring comprehensive regulatory support & CoA traceability for various grades with global supply capability with reliable lead time.
Palladium (Pd), a soft, silvery-white metal and critical member of the Platinum Group Metals (PGM) family, is foundational to modern industrial chemistry, valued both as a precious metal asset & a peerless catalyst. In primary industrial form, Palladium 10% on Carbon (Pd/C) (CAS: 7440-05-3) is a heterogeneous supported catalyst where precisely 10% (w/w) of highly dispersed Pd nanoparticles are anchored onto an activated carbon matrix to maximise its reactive surface area. This formulation is indispensable across the Pharmaceutical (API synthesis) and Fine Chemical sectors due to its unique capacity to efficiently adsorb and activate molecular hydrogen (H₂), thereby driving vital transformati...
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Industrial Chemicals, Metallurgy Chemicals
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Metal Compounds & Salts, Specialty Chemicals
Catalysts, Palladium Compounds
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Chemical Properties & Specifications
GHS02 (Flame)
Danger
UN3178 Flammable solid, inorganic, n.o.s.
H228 (31.5%): Flammable solid
H315 (17.7%): Causes skin irritation & H319 (18%): Causes serious eye irritation
H413 (17%): May cause long lasting harmful effects to aquatic life
Pyrophoric Danger (Spontaneous Ignition when dry, especially with adsorbed Hydrogen)
Strict inert atmosphere (Argon or Nitrogen) handling is mandatory. Use of explosion-proof equipment is required
P210, P240, P241, P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P405, and P501
4.1 (Flammable Solid)
(Debenzylation) Removal of Benzyl (Bn) protecting groups in complex API intermediates (e.g., cephalosporins, peptides) via Hydrogenolysis
(Hydrogenation) Selective reduction of nitro compounds to primary amines (a key step in dye/polymer/chemical precursor synthesis) and reduction of alkenes and alkynes
(Dehalogenation) Preferred for the reductive dehalogenation of aromatic halides (removal of Halogen atoms by Hydrogen).
As a heterogeneous catalyst, it is easily separated from the final product by simple filtration, reducing downstream purification costs for CDMOs
Store WET (wetted with water or appropriate solvent). NEVER allow the catalyst powder to dry out, as this is the condition that leads to spontaneous combustion in air.
Store Under Inert Gas (Nitrogen or Argon). This prevents oxidation and ignition, especially if the product is dry or contains residual hydrogen.
Store in a cool, dry, well-ventilated, and fire-resistant area. Keep away from any sources of ignition, heat, or hot surfaces.
Must be segregated from strong oxidizing agents, acids, bases, and alcohols (which can be easily ignited by dry Pd/C).
Pd/C is uniquely well-suited for debenzylation because the conditions required for this reaction are generally milder than those needed for reducing many other functional groups (like esters or amides). This allows for high selectivity, successfully cleaving the benzyl protecting group without damaging the rest of the complex API molecule.
Pd/C is insoluble in the reaction mixture, enabling its easy and cost-effective separation using simple filtration post-reaction. This simplifies the product workup, reduces product loss, and facilitates the crucial recovery of the expensive Palladium metal for reuse, making the overall process highly sustainable and economical.
Pd/C can be reused for multiple batch cycles, often after simple washing or regeneration. The carbon support's high surface area and stability contribute to the catalyst's robust performance, and CDMOs rely on professional palladium reclamation services to recover the metal efficiently once the catalyst is deactivated.
Sealed HDPE Drums or Airtight Metal Containers. The container must prevent the escape of moisture or the ingress of air.
Containers must be sealed with a positive pressure Nitrogen or Argon blanket over the wetted material. Essential to manage the Pyrophoric risk and preserve catalytic activity.
Must carry GHS Flame pictogram, the UN3178 Number, and a clear warning: "Keep Wet. Danger: Flammable Solid." Regulatory and safety compliance is critical for transportation and CDMO use.
