2-chloro-5-chloromethylthiazole

2-chloro-5-chloromethylthiazole

CAS Number
105827-91-6
Molecular Formula
C4H3Cl2NS
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About 2-chloro-5-chloromethylthiazole

2-Chloro-5-(chloromethyl)thiazole (CAS 105827-91-6) serves as a vital building block in the US API intermediates market, particularly for the synthesis of the HIV protease inhibitor Ritonavir, where a Pharma/API purity of 99% is mandatory to ensure stringent FDA compliance. CCMT has seen a significant surge in demand a...

2-chloro-5-chloromethylthiazole Specifications

CAS Number
105827-91-6
Molecular Formula
C4H3Cl2NS
Molecular Weight
168.04 g/mol
IUPAC Name
2-chloro-5-(chloromethyl)-1,3-thiazole
Canonical SMILES
C1=C(SC(=N1)Cl)CCl
InChI Key
VRMUIVKEHJSADG-UHFFFAOYSA-N
InChI
InChI=1S/C4H3Cl2NS/c5-1-3-2-7-4(6)8-3/h2H,1H2
EINECS Number
429-830-5
MDL Number
MFCD01073549
HSN No
29341000
Molecular Weight
168.04 g/mol
Melting Point
31°C
Boiling Point
268.6 °C at 760 mmHg
Freezing point
29-31°C
Flash Point
116.3 °C
Density
1.503±0.06 g/cm3
pKa
0.19±0.10(Predicted)
PSA
41.1 Ų
logP
2.3
Average mass
168.04 g/mol
Monoisotopic mass
166.9363257 Da
Molar mass
168.04 g/mol
Vapour pressure
0.0126mmHg at 25°C
Precautionary Statement Codes
P260, P273, P280, P301+P312, P303+P361+P353, P305+P351+P338, P304+P340+P310, P301+P330+P331, P308+P313, P333+P313, P361+P364, P391, P405, and P501
Hazard Classes and Categories
Acute Tox. 3 Dermal Acute Tox. 4 Oral

Pharmaceutical Intermediate

2-Chloro-5-chloromethylthiazole serves as a critical building block in the synthesis of pharmaceuticals, most notably Ritonavir, a second-generation anti-AIDS drug and selective HIV protease inhibitor used in viral treatment

Agrochemical Intermediate

The compound is a key precursor for manufacturing next-generation neonicotinoid insecticides such as Thiamethoxam and Clothianidin, providing high-efficiency pest control for sustainable agriculture

Organic Synthesis

It is utilized as a versatile heterocyclic building block in specialty chemical research for introducing thiazole moieties into complex molecules, antifungal agents, and advanced materials with properties like flame retardancy.

2-chloro-5-chloromethylthiazole FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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