Clobetasol propionate

CAS Number: 25122-46-7

Molecular Formula: C25H32ClFO5

Purity: Clobetasol propionate 98% purity

About Clobetasol propionate

Clobetasol propionate (CAS 25122-46-7) acts as a premier super-high-potency corticosteroid in the API intermediates market, essential for formulating advanced topical treatments for severe inflammatory dermatoses like plaque psoriasis and eczema where high purity fine chemicals (Pharma/API purity 99%) are a prerequisit...

Clobetasol propionate Specifications

CAS Number

25122-46-7

Molecular Formula

C25H32ClFO5

Molecular Weight

466.970

IUPAC Name

[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

Canonical SMILES

CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl

InChI Key

CBGUOGMQLZIXBE-XGQKBEPLSA-N

EINECS Number

246-634-3

MDL Number

MFCD00058499

HSN No

30049099

CAS Number

25122-46-7

Molecular Formula

C25H32ClFO5

Molecular Weight

466.970

IUPAC Name

[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

Canonical SMILES

CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl

InChI Key

CBGUOGMQLZIXBE-XGQKBEPLSA-N

EINECS Number

246-634-3

MDL Number

MFCD00058499

HSN No

30049099

Molecular Weight

466.970

PSA

80.670

LogP

4.10310

Density

1.28 g/cm3

Boiling Point

569ºC @ 760 mmHg

Melting Point

195.5-197ºC

Flash Point

297.9ºC

Refractive Index

1.56

Vapor Pressure

2.58E-15mmHg @ 25°C

Purity

Clobetasol propionate 98% purity

Safety Statement Codes

S26, S36

Risk Statement Codes

R36, 37, 38

Precautionary Statement Codes

P203, P260, P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Pharmaceutical Active Ingredient

A super-high potency topical corticosteroid used as the primary active component in various dermatological formulations including creams, ointments, gels, and shampoos to treat severe inflammatory skin conditions such as psoriasis, eczema, and lichen sclerosus

Anti-inflammatory Agent

A potent glucocorticoid receptor agonist that suppresses the production of pro-inflammatory cytokines and mediators to reduce swelling, redness, and itching