

Bis(4-nitrophenyl) carbonate (CAS No: 5070-13-3) is rapidly evolving as a high-performance alternative to phosgene in the global speciality chemicals market, primarily due to its utility as a safer, solid-state carbonylating agent for the synthesis of complex symmetrical and unsymmetrical ureas and carbamates. This reagent is gaining significant traction within the pharmaceutical CDMO sector, particularly in the production of therapeutic peptides and antibody-drug conjugates (ADCs) where its role in forming activated p-nitrophenyl esters ensures high coupling efficiency and precision in bioconjugation workflows. Furthermore, the compound is seeing expanded industrial adoption in polymer chemistry for the development of high-specification polycarbonate materials and as a cross-linking agent that enhances the thermal stability and mechanical integrity of advanced engineering plastics. We are an globally established Bis(4-nitrophenyl) carbonate intermediates supplier with >= 99% purity, ensuring minimal carry-over of impurities in the final API, and a broad range of various pharmaceutical intermediates for API manufacturers and finished formulators, providing comprehensive analytical (HPLC/NMR/MS) and supporting Bis(4-nitrophenyl) carbonate COA/TDS/SDS region-specific regulatory support, reliable lead times, and worldwide supply chain capabilities.

Bis(4-nitrophenyl) carbonate (CAS No: 5070-13-3) is rapidly evolving as a high-performance alternative to phosgene in the global speciality chemicals market, primarily due to its utility as a safer, solid-state carbonylating agent for the synthesis of complex symmetrical and unsymmetrical ureas and carbamates. This reagent is gaining significant traction within the pharmaceutical CDMO sector, particularly in the production of therapeutic peptides and antibody-drug conjugates (ADCs) where its role in forming activated p-nitrophenyl esters ensures high coupling efficiency and precision in bioconjugation workflows. Furthermore, the compound is seeing expanded industrial adoption in polymer chem...

Chemical Properties & Specifications
P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364
Skin Irrit. 2 (100%)
Eye Irrit. 2 (100%)
A coupling reagent used for the preparation of activated 4-nitrophenyl esters of N-protected amino acids
A stable, solid alternative to phosgene utilized for the synthesis of symmetrical and unsymmetrical ureas, carbamates, and carbonates
A versatile reagent used to link biomolecules to proteins and other carriers in drug delivery research
A functional building block for the synthesis of various pharmaceutical intermediates, agrochemicals, and high-performance polymers.
Bis(4-nitrophenyl) carbonate is a versatile organic compound used as a safer alternative to phosgene for carbonylation, acting as a reagent for the synthesis of carbonates, ureas, carbamates, and peptide coupling
This compound is widely utilized in the pharmaceutical, agrochemical, polymer chemistry, and materials science industries for drug development and the production of advanced materials
It is soluble in organic solvents such as chloroform, tetrahydrofuran, acetone, and dichloromethane, and is typically used in organic synthesis and liquid-phase protocols
Standard specifications include CAS number 5070-13-3, high purity (typically >98%), and availability of documentation such as COA, TDS, impurity reports, and regulatory compliance documents
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Active Pharmaceutical Ingredients (APIs)
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