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Benzyl (S,S,S)-2-azabicyclo[3.3.0]octane-3-carboxylate hydrochloride (CAS No: 87269-87-2) is a sophisticated chiral building block primarily utilised in the asymmetric synthesis of Ramipril, where the precise (S,S,S) stereochemistry is fundamental to the therapeutic potency of the resulting ACE inhibitor. The increasing prevalence of hypertension and cardiovascular diseases worldwide sustains a robust high-volume requirement for this bicyclic heterocyclic precursor, encouraging the adoption of advanced process chemistry and green synthesis methods to optimise yields and atom economy. As global regulatory bodies heighten scrutiny on isomeric purity and potential genotoxic impurities, there is a distinct market trend toward sourcing from suppliers who provide exhaustive analytical dossiers and maintain robust quality management systems within the pharmaceutical supply chain. We are an globally established Benzyl (S,S,S)-2-azabicyclo octane-3-carboxylate hydrochloride intermediates supplier with >= 99% purity, ensuring minimal carry-over of impurities in the final API, and a broad range of various pharmaceutical intermediates for API manufacturers and finished formulators, providing comprehensive analytical (HPLC/NMR/MS) and supporting Benzyl (S,S,S)-2-azabicyclo octane-3-carboxylate hydrochloride COA/TDS/SDS region-specific regulatory support. reliable lead times, worldwide supply chain capabilities.
Benzyl (S,S,S)-2-azabicyclo[3.3.0]octane-3-carboxylate hydrochloride (CAS No: 87269-87-2) is a sophisticated chiral building block primarily utilised in the asymmetric synthesis of Ramipril, where the precise (S,S,S) stereochemistry is fundamental to the therapeutic potency of the resulting ACE inhibitor. The increasing prevalence of hypertension and cardiovascular diseases worldwide sustains a robust high-volume requirement for this bicyclic heterocyclic precursor, encouraging the adoption of advanced process chemistry and green synthesis methods to optimise yields and atom economy. As global regulatory bodies heighten scrutiny on isomeric purity and potential genotoxic impurities, there is...
Chemical Properties & Specifications
P203, P261, P264, P270, P272, P280, P301+P316, P302+P352, P318, P321, P330, P333+P317, P362+P364, P405, and P501
Acute Tox. 3 (100%)
Skin Sens. 1 (100%)
An intermediate used in the preparation of ramipril, an angiotensin-converting enzyme (ACE) inhibitor
A starting material for the synthesis of octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as potent DPP4 inhibitors
A reference material for Abbreviated New Drug Applications (ANDA) and New Drug Applications (NDA) in the commercial manufacturing of Ramipril
A chiral building block used in asymmetric synthesis and medicinal chemistry for the design of enzyme inhibitors and bioactive molecules
Benzyl (S,S,S)-2-azabicyclo octane-3-carboxylate hydrochloride is a chiral bicyclic amino acid ester derivative with the molecular formula C15H19NO2·HCl, primarily used as a key pharmaceutical intermediate in the synthesis of ramipril, an angiotensin-converting enzyme (ACE) inhibitor, and other bioactive molecules like DPP4 inhibitors
This compound is heavily utilized in the pharmaceutical industry, specifically within medicinal chemistry, asymmetric organic synthesis, and commercial API manufacturing
It is primarily compatible with organic synthesis protocols, showing moderate solubility in polar organic solvents like methanol and dimethyl sulfoxide, and poor solubility in water
Standard specifications include CAS number 87269-87-2, a molecular weight of 281.78 g/mol, a purity typically ≥98.0% by HPLC, and documentation such as COA, TDS, impurity reports, and regulatory compliance documents
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Active Pharmaceutical Ingredients (APIs)
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