Adapalene USP/BP

CAS Number: 106685-40-9

Molecular Formula: C28H28O3

Purity: Adapalene 98% purity

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About Adapalene USP/BP

Adapalene (CAS 106685-40-9) represents a cornerstone in the topical retinoid sector of the API intermediates market, where its unique selective binding to retinoic acid receptors makes it indispensable for manufacturing advanced acne and photoaging treatments requiring high purity fine chemicals (Pharma/API purity 99% ...

Adapalene USP/BP Specifications

CAS Number

106685-40-9

Molecular Formula

C28H28O3

Molecular Weight

412.52 g/mol

IUPAC Name

6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid

Canonical SMILES

COc1ccc(cc1C12CC3CC(C2)CC(C1)C3)c1ccc2c(c1)ccc(c2)C(=O)O

InChI Key

LZCDAPDGXCYOEH-UHFFFAOYSA-N

HSN No

29163990

CAS Number

106685-40-9

Molecular Formula

C28H28O3

Molecular Weight

412.52 g/mol

IUPAC Name

6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid

Canonical SMILES

COc1ccc(cc1C12CC3CC(C2)CC(C1)C3)c1ccc2c(c1)ccc(c2)C(=O)O

InChI Key

LZCDAPDGXCYOEH-UHFFFAOYSA-N

HSN No

29163990

Molecular Weight

412.52 g/mol

Purity

Adapalene 98% purity

Physical appearance

White to light yellow powder to crystal

Melting Point

319-322 °C

Boiling Point

606.3±55.0 °C (Predicted)

Freezing point

319°C

logP

6.917

Precautionary Statement Codes

P203, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

Skin Irrit. 2 (72.7%) Eye Irrit. 2 (72.7%)

Active Pharmaceutical Ingredient

A topical retinoid used primarily in the formulation of gels, creams, and lotions for the treatment of acne vulgaris by modulating cellular keratinization and inflammatory processes

Retinoic Acid Receptor (RAR) Agonist

A selective agonist for RARβ and RARγ receptors employed in biochemical research to study gene transcription, cell differentiation, and the inhibition of hepatitis B virus transcription

Cell Culture Supplement

A component used in the culturing of peripheral blood mononuclear cells (PBMC) and mixed lymphocyte reactions (MLR) to investigate effects on isolated macrophages

Pharmaceutical Secondary Standard

A certified reference material utilized in analytical laboratory testing and quality control assays for peak identification and potency verification according to USP/EP monographs.