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Adapalene (CAS 106685-40-9) represents a cornerstone in the topical retinoid sector of the API intermediates market, where its unique selective binding to retinoic acid receptors makes it indispensable for manufacturing advanced acne and photoaging treatments requiring high purity fine chemicals (Pharma/API purity 99% | General Industry purity 98%). 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid serves as a high-performance active ingredient in the current landscape of strategic global sourcing, as CDMOs increasingly utilize custom synthesis services to ensure rigorous control over crystalline polymorphism and impurity profiles in accordance with evolving ICH guidelines. 1-(3-Admantyl-4-methoxyphenyl)-2-naphthoic acid remains a preferred choice for bulk chemical supplier procurement due to its superior photostability and reduced irritation profile compared to first-generation retinoids, reflecting a growing industry demand for reliable precursors that optimize formulation stability (Pharma/API purity 99% | General Industry purity 98%). We are an established Adapalene USP/BP api supplier with >= 99% purity globally for semi-finished formulators, providing comprehensive analytical (HPLC/NMR/MS) and supporting Adapalene USP/BP COA/TDS/SDS region-specific regulatory support. reliable lead times, worldwide supply chain capabilities
Adapalene (CAS 106685-40-9) represents a cornerstone in the topical retinoid sector of the API intermediates market, where its unique selective binding to retinoic acid receptors makes it indispensable for manufacturing advanced acne and photoaging treatments requiring high purity fine chemicals (Pharma/API purity 99% | General Industry purity 98%). 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid serves as a high-performance active ingredient in the current landscape of strategic global sourcing, as CDMOs increasingly utilize custom synthesis services to ensure rigorous control over crystalline polymorphism and impurity profiles in accordance with evolving ICH guidelines. 1-(3-Admantyl-...
Chemical Properties & Specifications
P203, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Skin Irrit. 2 (72.7%)
Eye Irrit. 2 (72.7%)
A topical retinoid used primarily in the formulation of gels, creams, and lotions for the treatment of acne vulgaris by modulating cellular keratinization and inflammatory processes
A selective agonist for RARβ and RARγ receptors employed in biochemical research to study gene transcription, cell differentiation, and the inhibition of hepatitis B virus transcription
A component used in the culturing of peripheral blood mononuclear cells (PBMC) and mixed lymphocyte reactions (MLR) to investigate effects on isolated macrophages
A certified reference material utilized in analytical laboratory testing and quality control assays for peak identification and potency verification according to USP/EP monographs.
Adapalene USP/BP is a third-generation topical retinoid and naphthoic acid derivative used primarily for the treatment of mild to moderate acne vulgaris by regulating skin cell turnover and providing anti-inflammatory effects
This compound is primarily used in the pharmaceutical and skincare industries for the production of prescription and over-the-counter acne treatments
Adapalene USP/BP is compatible with topical formulations such as aqueous gels, creams, lotions, and solutions, and is typically soluble in tetrahydrofuran or dimethyl sulfoxide for analytical purposes
Standard specifications include CAS number 106685-40-9, high purity (98.0% to 102.0% on a dried basis), and availability of documentation such as COA, TDS, impurity reports, and regulatory compliance documents
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Active Pharmaceutical Ingredients (APIs)
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