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The synthesis of (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone (CAS 461432-22-4) requires precise control over Friedel-Crafts acylation and subsequent purification protocols to ensure the stringent impurity profiles required for pharmaceutical-grade chemicals. Our GMP manufacturing capabilities allow us to manage the exothermic nature of these reactions while maintaining high yields and isomeric purity. This stage 1 intermediate is characterised by its dual-halogenated structure, which offers a unique "synthetic handle" for further chemical functionalisation. By providing a reliable supply of this advanced Dapagliflozin Stage-1 intermediate, we enable pharmaceutical innovators to bypass early-stage process hurdles and focus on API scale-up and clinical validation. Our expertise in custom synthesis ensures that each batch is delivered with the exact physical characteristics, including particle size & moisture content, necessary for seamless integration into the next synthetic stage. This technical rigour reduces the overall risk in the drug development lifecycle, ensuring that the "Total Cost of Quality" is minimised through high process reproducibility and superior chemical stability. We are an established Dapagliflozin intermediate supplier, ensuring consistent high purity Dapagliflozin Stage-1. Being recognised as a CDMO partner for advanced pharmaceutical intermediates and a regulatory-compliant holder for global drug manufacturing chains, we provide a broad range of precursors with comprehensive analytical documentation (HPLC, GC-MS, NMR) and supporting quality assurance (Dapagliflozin COA/SDS/TDS). Our facilities are optimised for commercial-scale production and custom synthesis, offering a stable foundation for SGLT2 inhibitor manufacturing. We ensure reliable lead times and transparent project management, enabling partners to lead in high-precision pharmaceutical development.
The synthesis of (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone (CAS 461432-22-4) requires precise control over Friedel-Crafts acylation and subsequent purification protocols to ensure the stringent impurity profiles required for pharmaceutical-grade chemicals. Our GMP manufacturing capabilities allow us to manage the exothermic nature of these reactions while maintaining high yields and isomeric purity. This stage 1 intermediate is characterised by its dual-halogenated structure, which offers a unique "synthetic handle" for further chemical functionalisation. By providing a reliable supply of this advanced Dapagliflozin Stage-1 intermediate, we enable pharmaceutical innovators to bypass ...
Chemical Properties & Specifications
Primary precursor for the synthesis of C-glycoside derivatives used in the management of Type 2 diabetes
Versatile scaffold for the introduction of various functional groups via cross-coupling reactions (e.g., Suzuki, Heck, or Buchwald-Hartwig) at the bromo-site
Preferred in the multi-stage synthesis of proprietary drug candidates, offering high regiospecificity and structural integrity for downstream transformations
Essential building block in the development of specialised agrochemicals and advanced materials requiring halogenated diaryl structures
Supports high-throughput screening and early-phase drug discovery by providing consistent, high-purity molecular frameworks
Our high-purity advanced intermediate synthesis platform specializes in the production of complex diaryl methanones, which serve as foundational building blocks for SGLT2 inhibitors and other bioactive molecules. As a vertically integrated CDMO partner, we offer robust pathways for the synthesis of (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone, a critical stage-1 intermediate in the Dapagliflozin manufacturing lifecycle.
Diaryl methanone synthesis often involves Lewis acid-catalyzed acylation, which can lead to unwanted isomer formation and heavy metal contamination. Our process optimization team utilizes proprietary purification techniques and controlled reaction kinetics to achieve high isomeric selectivity. This ensures that the Stage-1 intermediate is free from significant ortho/para impurities, which is critical for maintaining the stoichiometric efficiency of downstream API scale-up steps.
Yes. Through our custom synthesis services, we can offer derivatives or analogues of this structure to support SAR (Structure-Activity Relationship) studies. Our technical writers and chemists work closely with client R&D teams to provide specific polymorphs or moisture-controlled grades, establishing our authority as a flexible and responsive manufacturing partner for innovator firms.
Given its role as a key precursor, supply chain stability is paramount. We support commercial-scale requirements with a standard lead time of 10–12 weeks. All materials are shipped in double PE-lined fiber drums with appropriate GHS labeling and a comprehensive Dapagliflozin intermediate Stage-1 COA . Our integrated logistics ensure that moisture-sensitive intermediates are protected during international transit, satisfying the technical audits of global pharmaceutical chains.
While this is a Stage-1 intermediate, we maintain rigorous traceability and safety data. Each batch is supplied with an Dapagliflozin SDS and a detailed technical data sheet. We support our partners with the necessary documentation to satisfy Drug Master File (DMF) requirements, ensuring that the starting materials used in your manufacturing process meet the expectations of global health authorities (FDA/EMA).
The moq is shared upon RFI orientation and for Dapagliflozin Stage-1 bulk wholesale.
