

4-Cyanopyridine (4CP), or Isonicotinonitrile (CAS 100-48-1), is a critical C6 nitrogen-containing Heterocyclic Building Block indispensable to the synthesis of complex fine chemicals and pharmaceutical actives. As a versatile organic intermediate, 4CP possesses a functional nitrile group (-CN) attached to the C4 position of the pyridine ring, enabling chemists to perform a wide range of transformations. 4CP's primary industrial route is the high-yield Ammoxidation of 4-methylpyridine (4-Picoline). Pyridine-4-carbonitrile's value in the API & CDMO sector is rooted in its role as a direct precursor to Isonicotinic Acid and, most notably, the essential anti-tuberculosis drug Isoniazid (INH). Aside this, Pyridine Carbonitrile is a key reagent in the preparation of the powerful organocatalyst 4-Dimethylaminopyridine (DMAP), a globally preferred coupling agent. 4CP (4-Pyridinecarbonitrile) is produced in pharmaceutical or technical grades by 4-Cyanopyridine manufacturers, ensuring the stringent purity standards (typically > 99%) required for subsequent sensitive synthetic steps. We are the leading 4-Cyanopyridine supplier worldwide ensuring comprehensive regulatory support & CoA traceability for various grades with global supply capability with reliable lead time.

4-Cyanopyridine (4CP), or Isonicotinonitrile (CAS 100-48-1), is a critical C6 nitrogen-containing Heterocyclic Building Block indispensable to the synthesis of complex fine chemicals and pharmaceutical actives. As a versatile organic intermediate, 4CP possesses a functional nitrile group (-CN) attached to the C4 position of the pyridine ring, enabling chemists to perform a wide range of transformations. 4CP's primary industrial route is the high-yield Ammoxidation of 4-methylpyridine (4-Picoline). Pyridine-4-carbonitrile's value in the API & CDMO sector is rooted in its role as a direct precursor to Isonicotinic Acid and, most notably, the essential anti-tuberculosis drug Isoniazid (INH). Aside this, Pyridine Carbonitrile is a key reagent in the preparation of the powerful organocatalyst 4-Dimethylaminopyridine (DMAP), a globally preferred coupling agent. 4CP (4-Pyridinecarbonitrile) is produced in pharmaceutical or technical grades by 4-Cyanopyridine manufacturers, ensuring the stringent purity standards (typically > 99%) required for subsequent sensitive synthetic steps. We are the leading 4-Cyanopyridine supplier worldwide ensuring comprehensive regulatory support & CoA traceability for various grades with global supply capability with reliable lead time.
Pharmaceutical
Pharmaceutical Actives & Precursors
Intermediates & Precursors

Chemical Properties & Specifications
H302 (94.9%): Harmful if swallowed
H312 (58.2%): Harmful in contact with skin
H319 (43%): Causes serious eye irritation
H332 (58.2%): Harmful if inhaled
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P321, P330, P337+P317, P362+P364, and P501
Key Intermediate in the synthesis of a variety of drugs. The nitrile (-CN) group is readily hydrolyzed to a carboxylic acid (-COOH) or reduced to an amine (-CH2NH2)
Precursor for the synthesis of complex pyridine derivatives, including the powerful nucleophilic catalyst 4-Dimethylaminopyridine (DMAP)
Intermediate in the development of certain pesticides and herbicides that incorporate the pyridine ring structure.