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4-Chlorobutyryl Chloride is an active acid chloride intermediate predominantly utilized in the pharmaceutical, agrochemical, and polymer sectors. It is structurally obtained from γ-chlorobutyric acid and serves as an essential building block for the synthesis of acylated compounds, particularly in the production of active pharmaceutical ingredients (APIs), fine chemicals, and specialty resins. Due to its combination of halogen and acyl functional groups, the compound demonstrates significant reactivity, making it useful in acylation processes, esterifications, and the development of chlorinated scaffolds.
4-Chlorobutyryl Chloride is an active acid chloride intermediate predominantly utilized in the pharmaceutical, agrochemical, and polymer sectors. It is structurally obtained from γ-chlorobutyric acid and serves as an essential building block for the synthesis of acylated compounds, particularly in the production of active pharmaceutical ingredients (APIs), fine chemicals, and specialty resins. Due to its combination of halogen and acyl functional groups, the compound demonstrates significant reactivity, making it useful in acylation processes, esterifications, and the development of chlorinated scaffolds.
Chemical Properties & Specifications
Skin Corrosion/Irritation: Category 1B Eye Damage: Category 1 Corrosive to Metals: Category 1
H314: Causes severe skin burns and eye damage H290: May be corrosive to metals H335: May cause respiratory irritation
P280: Wear protective gloves, goggles, and face shield P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting P303+P361+P353: IF ON SKIN: Remove contaminated clothing. Rinse with water
o Pharmaceuticals: Synthesis of intermediates for active pharmaceutical compounds o Agrochemicals: Precursor for herbicide and pesticide synthesis o Polymers: Used in chain-extension and acylation of specialty monomers o Fine Chemicals: For acyl chloride introduction in complex molecules
o Efficient chlorinated acylating agent o Enables multi-functional synthesis pathways o Preferred where dual halogen functions are needed
o Moisture-sensitive; requires nitrogen-blanketed filling o Highly reactive with alcohols and amines o Stored and handled under dry inert conditions o Used in fluorination, amidation, and esterification pathways
o Synthesis of chlorinated heterocycles, amide derivatives, & small-molecule drug scaffolds, particularly in oncology, anti-inflammatory, and CNS-targeted compounds. o Compatibility with amines, alcohols, and thiols makes it widely used in early-stage discovery as well as cGMP-scale synthesis workflows.
Store at 5–30°C, dry & well-ventilated
12–18 months sealed under nitrogen
25 kg HDPE or steel drum (with inert lining)
25 kg HDPE or steel drum (with inert lining)
UN 3265 | Corrosive Liquid, Organic
It is widely used as a reactive intermediate in the production of APIs, herbicides, and polymers.
No, it is highly moisture-sensitive and reacts exothermically with water.
Yes, supplied in UN-labeled DG-approved packaging with export clearance support.
Yes, MOQ-based pricing, OEM labeling, and inert-gas packaging available.
MOQ: 25–50 kg in HDPE drums with PTFE liner
Dispatch Time: 7–10 working days
Yes, Documentation: COA, MSDS, and moisture-sensitive handling guidelines
