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Our 3-(4-Chlorophenyl)Isoindolin-1-one is a high-purity crystalline intermediate belonging to the isoindolinone family. This compound is an essential "platform molecule" used in the multi-step synthesis of various tricyclic sympathomimetic agents, most notably Mazindol. Specialised heterocyclic organic building block primarily utilised as a high-value pharmaceutical intermediate & recognised as a key precursor in the synthesis of Mazindol (a potent anorexiant/appetite suppressant) and is also a documented impurity standard for the diuretic medication Chlorthalidone. In 2026, Phthalimidine, 3-(p-chlorophenyl)- is also highly sought after by quality control laboratories as a reference standard for Chlorthalidone impurity profiling. Featuring a robust chemical structure with a chlorophenyl substitution, it provides a stable foundation for a broad spectrum of biological activities, including antimicrobial and anxiolytic research. We offer this product at 98%+ purity, backed by comprehensive analytical data (NMR, HPLC) to support global API manufacturing and research requirements. We are globally established pharmaceutical suppliers, right from intermediate to semi-finished formulations / dosages, ensuring reliable lead times; comprehensive regulatory documentation (CoA); and consistent worldwide supply capabilities across all grades/forms/strengths.
Our 3-(4-Chlorophenyl)Isoindolin-1-one is a high-purity crystalline intermediate belonging to the isoindolinone family. This compound is an essential "platform molecule" used in the multi-step synthesis of various tricyclic sympathomimetic agents, most notably Mazindol. Specialised heterocyclic organic building block primarily utilised as a high-value pharmaceutical intermediate & recognised as a key precursor in the synthesis of Mazindol (a potent anorexiant/appetite suppressant) and is also a documented impurity standard for the diuretic medication Chlorthalidone. In 2026, Phthalimidine, 3-(p-chlorophenyl)- is also highly sought after by quality control laboratories as a reference standard...
Chemical Properties & Specifications
Eye Dam. 1 (100%)
P264+P265, P280, P305+P354+P338, and P317
Primary intermediate for the synthesis of Mazindol and related appetite suppressants
Reference standard (Impurity/Related Compound) for Chlorthalidone and other isoindoline-based diuretics
Scaffold in medicinal chemistry for developing new anti-arrhythmic, antimicrobial, and antipsychotic agents
Utilized in its deuterium-labeled form (d₄) as an internal standard for quantitative analysis by GC-MS and LC-MS.
2°C – 8°C (Refrigerator) for long-term stability
Mazindol is a tricyclic sympathomimetic agent first approved in 1973. This isoindolinone derivative serves as a critical synthetic intermediate; the synthesis typically involves the condensation of ethylenediamine with precursors like 2-(4-chlorobenzoyl)benzoic acid to form the isoindoline core.
Major stocks are held in and shipped from Hyderabad and ensuring rapid domestic delivery to pharmaceutical R&D centers.
In the scalable synthesis of Chlorthalidone, this compound (also known as 3-(4'-chlorophenyl)phthalimidine) acts as a pivotal advanced intermediate. It is typically synthesized from 2-(4-chlorobenzoyl)benzoic acid via a ring-contraction step using zinc dust and acetic acid. Once formed, the isoindolinone core is reacted with chlorosulfonic acid and a chlorinating agent (like POl) to introduce the sulfonyl group, which is later converted to the sulfonamide and hydroxylated at position 3 to yield the final Chlorthalidone API.
This molecule is officially categorized as a Drug Impurity Standard (e.g., Chlortalidone Impurity 8 or Deshydroxy Chlorthalidone). Regulatory bodies like the USP, EP, and BP require manufacturers to monitor its presence in the final API to ensure quality and safety. Analytical laboratories use high-purity (98%+) versions of this compound as a reference standard in HPLC and GC-MS testing to quantify process-related impurities and validate that the Chlorthalidone API meets stringent pharmacopoeial limits for commercial release.
Bulk Industrial/API Grade: Available via custom quotation from major manufacturing hubs in Hyderabad and other places in India.
The moq to Buy CAS 2224-77-3 Bulk India or international export shared upon on sourcing along with 3-(4-Chlorophenyl)Isoindolin-1-one Price, Chlorthalidone Related Compound coas.
