(2S, 2'S)-6-Fluoro-2-(2'-oxiranyl)chromane

CAS Number: 876514-31-7

Molecular Formula: C11H11FO2

(2S2'S)-6-Fluoro-2-(2'-oxiranyl)chromane supplierbuy 129050-23-3nebivolol intermediate manufacturerspharmaceutical grade 6-fluoro-2-(oxiran-2-yl)chromanechemical impurity standardsnebivolol SSSS isomer price

About (2S, 2'S)-6-Fluoro-2-(2'-oxiranyl)chromane

(2S)-2-((2S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)oxirane (CAS 129050-23-3) is a critical chiral building block in the API intermediates market, primarily utilized for the stereoselective synthesis of Nebivolol, a highly selective beta-1 adrenergic receptor blocker. As a bulk chemical supplier, we see a distinct s...

Synonyms

129050-23-3
(2S, 2'S)-6-Fluoro-2-(2'-oxiranyl)chromane
(2S)-6-Fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene
(2R)-rel-6-Fluoro-3,4-dihydro-2-(2R)-2-oxiranyl-2H-1-benzopyran
876514-31-7

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(2S, 2'S)-6-Fluoro-2-(2'-oxiranyl)chromane Specifications

CAS Number

876514-31-7

Molecular Formula

C11H11FO2

Molecular Weight

194.21 g/mol

IUPAC Name

(2S)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-chromene

Canonical SMILES

C1CC2=C(C=CC(=C2)F)OC1C3CO3

InChI Key

GVZDIJGBXSDSEP-QWRGUYRKSA-N

InChI

InChI=1S/C11H11FO2/c12-8-2-4-9-7(5-8)1-3-10(14-9)11-6-13-11/h2,4-5,10-11H,1,3,6H2/t10-,11-/m0/s1

EINECS Number

603-314-1

MDL Number

MFCD03423727

HSN No

29329900

CAS Number

876514-31-7

Molecular Formula

C11H11FO2

Molecular Weight

194.21 g/mol

IUPAC Name

(2S)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-chromene

Canonical SMILES

C1CC2=C(C=CC(=C2)F)OC1C3CO3

InChI Key

GVZDIJGBXSDSEP-QWRGUYRKSA-N

InChI

InChI=1S/C11H11FO2/c12-8-2-4-9-7(5-8)1-3-10(14-9)11-6-13-11/h2,4-5,10-11H,1,3,6H2/t10-,11-/m0/s1

EINECS Number

603-314-1

MDL Number

MFCD03423727

HSN No

29329900

Molecular Weight

194.21 g/mol

Melting Point

Boiling Point

291.7±40.0 °C (Predicted)

Flash Point

137.8°C

Density

1.25 g/cm3 at 20℃

PSA

202.3 Å²

logP

2.2-5.2

Average mass

194.21 g/mol

Monoisotopic mass

194.07430775 Da

Molar mass

194.21 g/mol

Vapour pressure

0.14-0.25Pa at 20-25℃

Precautionary Statement Codes

P203, P264, P270, P280, P301+P317, P302+P352, P305+P351+P338, P318, P321, P330, P332+P317, P337+P317, P362+P364, P405, and P501

Hazard Classes and Categories

Acute Tox. 4 (100%) Eye Irrit. 2 (100%)

Pharmaceutical Intermediate

(2S, 2'S)-6-Fluoro-2-(2'-oxiranyl)chromane is primarily utilized as a chiral building block and key intermediate in the synthesis of Nebivolol, a highly cardioselective vasodilatory beta-receptor blocker used for the treatment of hypertension

Organic Synthesis

The compound serves as a valuable reagent and fine chemical in the production of enantiopure bioactive molecules, where its specific stereochemistry is critical for the development of active pharmaceutical ingredients

Biochemical Research

It is employed in laboratory studies as a tool for peptide engineering and the development of amino acid derivatives to investigate protein synthesis and metabolic pathways.