Search through
(2S)-2-((2S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)oxirane (CAS 129050-23-3) is a critical chiral building block in the API intermediates market, primarily utilized for the stereoselective synthesis of Nebivolol, a highly selective beta-1 adrenergic receptor blocker. As a bulk chemical supplier, we see a distinct shift toward CDMOs requiring high purity fine chemicals (Pharma/API purity 99%) to ensure the precise diastereomeric ratios necessary for finished dosage forms in cardiovascular therapy. (S)-6-Fluoro-2-((S)-oxiran-2-yl)chromane (CAS 129050-23-3) serves as a fundamental intermediate for medicinal chemistry, where the control of its two chiral centers is paramount for reducing impurity profiles in drug substance manufacturing. Current global sourcing shifts favor audited facilities that offer custom synthesis services and robust analytical validation to meet the tightening ICH Q3A/B guidelines for organic impurities (Pharma/API purity 99%). (-)-Nebivolol Intermediate (CAS 129050-23-3) is increasingly in demand as pharmaceutical manufacturers focus on cost-effective, convergent synthetic routes for next-generation antihypertensive agents. The industry trend toward sustainable green chemistry and secure supply chains has reinforced the need for a reliable bulk chemical supplier capable of delivering consistent batches with minimal residual solvents and heavy metal content (Pharma/API purity 99% | General Industry purity 98%). We are an established global intermediates supplier with >= 99% purity, ensuring minimal carry-over of impurities in the final API, and a broad range of various pharmaceutical intermediates for API manufacturers and finished formulators, providing comprehensive analytical (HPLC/NMR/MS) and supporting (2S, 2'S)-6-Fluoro-2-(2'-oxiranyl)chromane COA/TDS/SDS region-specific regulatory support, reliable lead times, and worldwide supply chain capabilities.
(2S)-2-((2S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)oxirane (CAS 129050-23-3) is a critical chiral building block in the API intermediates market, primarily utilized for the stereoselective synthesis of Nebivolol, a highly selective beta-1 adrenergic receptor blocker. As a bulk chemical supplier, we see a distinct shift toward CDMOs requiring high purity fine chemicals (Pharma/API purity 99%) to ensure the precise diastereomeric ratios necessary for finished dosage forms in cardiovascular therapy. (S)-6-Fluoro-2-((S)-oxiran-2-yl)chromane (CAS 129050-23-3) serves as a fundamental intermediate for medicinal chemistry, where the control of its two chiral centers is paramount for reducing imp...
Chemical Properties & Specifications
P203, P264, P270, P280, P301+P317, P302+P352, P305+P351+P338, P318, P321, P330, P332+P317, P337+P317, P362+P364, P405, and P501
Acute Tox. 4 (100%)
Eye Irrit. 2 (100%)
(2S, 2'S)-6-Fluoro-2-(2'-oxiranyl)chromane is primarily utilized as a chiral building block and key intermediate in the synthesis of Nebivolol, a highly cardioselective vasodilatory beta-receptor blocker used for the treatment of hypertension
The compound serves as a valuable reagent and fine chemical in the production of enantiopure bioactive molecules, where its specific stereochemistry is critical for the development of active pharmaceutical ingredients
It is employed in laboratory studies as a tool for peptide engineering and the development of amino acid derivatives to investigate protein synthesis and metabolic pathways.
(2S, 2'S)-6-Fluoro-2-(2'-oxiranyl)chromane is a chemical intermediate and impurity used primarily in the synthesis and research of the cardiovascular drug Nebivolol
This compound is widely used in the pharmaceutical, biotechnology, and life sciences research industries for drug development and analytical testing
It is compatible with organic solvents such as chloroform, dichloromethane, ethyl acetate, and methanol, and is typically used in synthetic laboratory protocols
Standard specifications include CAS number 129050-23-3, high purity (typically >=97% or 98%), and documentation such as COA, TDS, impurity reports, and regulatory compliance documents
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the specific shipping destination and regulatory requirements.
