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1-Bromo-5-chloropentane (54512-75-3 and 5451-27-5) is a high-purity, bifunctional halogenated alkane that serves as a flexible "carbon-5" linker in advanced chemical synthesis. Much like its shorter-chain analogs, this molecule features a terminal bromine and a terminal chlorine on a pentane backbone, offering differential reactivity. The bromine atom is significantly more labile, allowing for selective nucleophilic substitution at one end of the chain while keeping the chlorine end available for subsequent functionalisation. This specific chain length is critical in the pharmaceutical industry for the synthesis of long-chain aliphatic spacers in APIs and in agrochemicals for creating targeted heterocyclic frameworks. By ensuring high isomeric purity and minimal moisture content, 1-Bromo-5-chloropentane provides a reliable path for high-yield, complex molecular assembly. We are a globally established 1-Bromo-5-chloropentane manufacturer & 3-Bromopropylamine hydrobromide manufacturer and various other fine chemical intermediate suppliers worldwide through comprehensive regulatory documentation (CoA), traceability, and consistent global supply capabilities, ensuring reliable lead times and quality assurance across all grades.
1-Bromo-5-chloropentane (54512-75-3 and 5451-27-5) is a high-purity, bifunctional halogenated alkane that serves as a flexible "carbon-5" linker in advanced chemical synthesis. Much like its shorter-chain analogs, this molecule features a terminal bromine and a terminal chlorine on a pentane backbone, offering differential reactivity. The bromine atom is significantly more labile, allowing for selective nucleophilic substitution at one end of the chain while keeping the chlorine end available for subsequent functionalisation. This specific chain length is critical in the pharmaceutical industry for the synthesis of long-chain aliphatic spacers in APIs and in agrochemicals for creating target...
Chemical Properties & Specifications
Acute Tox. 4 (28.6%)
Skin Irrit. 2 (85.7%)
Skin Mild Irrit. 3 (14.3%)
Eye Irrit. 2A (85.7%)
STOT SE 3 (57.1%)
Aquatic Chronic 2 (28.6%)
P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501
Extensively used to introduce a 5-carbon spacer into drug molecules. Essential for modulating the lipophilicity and bioavailability of various central nervous system (CNS) and cardiovascular agents
Key precursor for the synthesis of Piperidine and Azepane derivatives through cyclization reactions with primary amines
Utilised in the functionalisation of polymers and lipids for controlled-release drug delivery platforms
Building block for the synthesis of various insect pheromones and semiochemicals used in (IPM)
Specialized chlorinated precursors that enhance the soil penetration and systemic uptake of active ingredients
Employed to graft functional groups onto polymer surfaces or silica beads for chromatography and ion-exchange applications
Synthesize long-chain cationic surfactants with specific hydrophobic-hydrophilic balances
Store in a cool, dry area (15-25°C)
Keep the container hermetically sealed
Hygroscopic-material readily absorbs moisture from the air, which can cause caking and potential hydrolysis of the C-Br bond over long periods
Avoid contact with strong oxidizing agents and strong bases
Strong bases will liberate the free amine, which may lead to polymerization (self-alkylation)