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1-Bromo-2-methylpropane (CAS NO : 78-77-3)

1-Bromo-2-methylpropane (CAS 78-77-3) serves as a critical alkylating agent in fine chemical synthesis, particularly valued for its ability to introduce the isobutyl group into complex molecular architectures such as the pharmaceutical intermediate isobutylboronic acid used in bortezomib production. Its superior leaving group ability compared to chlorinated analogues facilitates more efficient SN2 and E2 reaction pathways, making it a preferred reagent for researchers and drug development professionals seeking to optimise synthetic yields and reaction kinetics. Furthermore, the compound’s utility extends into the polymer chemistry and agrochemical sectors, where its high purity and specific reactivity support the development of high-performance materials and specialised crop protection agents. As a globally established 1-Bromo-2-methylpropane supplier with 99% purity, we ensure dependable supply, consistent quality, and complete regulatory documentation, including 1-Bromo-2-methylpropane CoA and 1-Bromo-2-methylpropane TDS across all grades. Beyond supply, we support partners through the entire product lifecycle from route scouting, process and formulation development, and analytical method development to scale-up, process optimisation, and pilot-to-commercial manufacturing. Our teams also assist with GMP-compliant quality assurance, regulatory documentation, and global supply chain and logistics coordination.

1-Bromo-2-methylpropane

1-Bromo-2-methylpropane (CAS 78-77-3) serves as a critical alkylating agent in fine chemical synthesis, particularly valued for its ability to introduce the isobutyl group into complex molecular architectures such as the pharmaceutical intermediate isobutylboronic acid used in bortezomib production. Its superior leaving group ability compared to chlorinated analogues facilitates more efficient SN2 and E2 reaction pathways, making it a preferred reagent for researchers and drug development professionals seeking to optimise synthetic yields and reaction kinetics. Furthermore, the compound’s utility extends into the polymer chemistry and agrochemical sectors, where its high purity and specific ...

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Chemical Properties & Specifications

Applications of 1-Bromo-2-methylpropane

Organic Synthesis

A versatile building block and alkyl halide used for the creation of complex molecules, including pharmaceuticals and agrochemicals

Synthetic Reagent

A reagent primarily used to introduce the isobutyl group in organic synthesis, such as the preparation of 1-ethyl-1,3-isobutylimidazolium bromide

Pharmaceutical Intermediate

A key precursor used to synthesize isobutylbenzene for the production of Ibuprofen and isobutylboronic acid for the synthesis of Bortezomib

Chemical Solvent

A medium used in various laboratory chemical reactions to enhance reaction rates and yields

Industrial Intermediate

An important intermediate used in the manufacturing of plastics, coatings, dyes, and specialty chemicals like surfactants or lubricants

Have Questions About 1-Bromo-2-methylpropane?
We've Got Answers.

1-Bromo-2-methylpropane, also known as isobutyl bromide, is a halogenated alkane that serves as a versatile building block and synthetic reagent in organic chemistry. It is primarily used to introduce isobutyl groups in the synthesis of various complex molecules, including pharmaceuticals and agrochemicals

This compound is widely utilized in the pharmaceutical, agrochemical, and specialty chemical industries, as well as in research laboratories for studying reaction mechanisms and developing plastics and coatings

It is a colorless liquid that is slightly soluble in water but miscible with organic solvents like ethanol and ether, making it suitable for liquid-phase synthesis and as a solvent in laboratory settings

Standard specifications include CAS number 78-77-3, high purity levels (typically ≥97% or ≥99% by GC), and technical documentation such as COA, TDS, impurity reports, and regulatory compliance documents

Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time

The product is export ready with a generally accepted MOQ starting from 100 kgs, though lead times for international customers vary based on shipping destination and grade.

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