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(S)-(+)-2-Chlorophenylglycine methyl ester (CAS NO : 141109-14-0)

Methyl (alphaS)-alpha-amino-2-chlorobenzeneacetate is the methyl ester of a specific enantiomer, meaning it is a chiral intermediate. It is derived from 2-(2-chlorophenyl)glycine through a process that involves esterification and enantiomeric resolution. In the synthesis of clopidogrel, the racemic 2-(2-chlorophenyl)glycine is often prepared first. Then, through processes like esterification and resolution, the desired (S)-enantiomer of the methyl ester, Methyl (alphaS)-alpha-amino-2-chlorobenzeneacetate is obtained, which is then used in subsequent steps to form the final drug product. Methyl (alphaS)-alpha-amino-2-chlorobenzeneacetate is the methyl ester of a specific enantiomer, meaning it is a chiral intermediate. 2-(2-Chlorophenyl)glycine (CAS 141196-64-7) and Methyl (alphaS)-alpha-amino-2-chlorobenzeneacetate (CAS 141109-14-0), can function as intermediates in the synthesis of pharmaceuticals, particularly clopidogrel. However, their roles are distinct stages in the overall process.

(S)-(+)-2-Chlorophenylglycine methyl ester
(S)-(+)-2-Chlorophenylglycine methyl ester

Methyl (alphaS)-alpha-amino-2-chlorobenzeneacetate is the methyl ester of a specific enantiomer, meaning it is a chiral intermediate. It is derived from 2-(2-chlorophenyl)glycine through a process that involves esterification and enantiomeric resolution. In the synthesis of clopidogrel, the racemic 2-(2-chlorophenyl)glycine is often prepared first. Then, through processes like esterification and resolution, the desired (S)-enantiomer of the methyl ester, Methyl (alphaS)-alpha-amino-2-chlorobenzeneacetate is obtained, which is then used in subsequent steps to form the final drug product. Methyl (alphaS)-alpha-amino-2-chlorobenzeneacetate is the methyl ester of a specific enantiomer, meaning i...

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Pharmaceutical

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Pharmaceutical Actives & Precursors

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Intermediates & Precursors

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Chemical Properties & Specifications

Identifiers of (S)-(+)-2-Chlorophenylglycine methyl ester

Canonical Smiles
COC(=O)C(C1=CC=CC=C1Cl)N
Inchi Key
UTWOZNRDJNWTPS-QMMMGPOBSA-N
Inchi
1S/C9H10ClNO2/c1-13-9(12)8(11)6-4-2-3-5-7(6)10/h2-5,8H,11H2,1H3/t8-/m0/s1
CAS Number
141109-14-0
Molecular Formula
C9H10ClNO2
IUPAC
methyl (2S)-2-amino-2-(2-chlorophenyl)acetate

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