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Rabeprazole Sodium (CAS NO : 117976-90-6)

Rabeprazole Sodium or (Rabeprazole na) a proton pump inhibitor (PPI) that suppresses gastric acid secretion by inhibiting the H⁺/K⁺-ATPase enzyme system at the secretory surface of gastric parietal cells, an action that leads to a reduction in gastric acidity, providing relief from acid-related disorders. Rabeprazole treats gastro-oesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. The compound exhibits hygroscopic properties, to be specific. Rabeprazole sodium, also known as Rabeprazole sodium salt, is preferred by manufacturers in the pharmaceutical industry for the production of oral dosage forms, such as enteric-coated tablets and capsules, designed to treat acid-related gastrointestinal disorders. Rabeprazole Sodium is a Proton Pump Inhibitor (PPI); Acid-Suppressing Agent; Delayed-Release API for GI Disorders. We are an established Rabeprazole Sodium api supplier at >99% purity, ensuring minimal carryover of impurities in the final API, and a broad range of various pharmaceutical apis providing comprehensive analytical (HPLC/NMR/MS) and supporting quality assurance documentation (COA/TDS/SDS) across all grades, detailed impurity mapping, and region-specific regulatory support. We ensure reliable lead times from R&D quantities through commercial-scale manufacturing, enabling partners to meet diverse global and regional requirements.

Rabeprazole Sodium
Rabeprazole Sodium
Rabeprazole Sodium

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Rabeprazole Sodium or (Rabeprazole na) a proton pump inhibitor (PPI) that suppresses gastric acid secretion by inhibiting the H⁺/K⁺-ATPase enzyme system at the secretory surface of gastric parietal cells, an action that leads to a reduction in gastric acidity, providing relief from acid-related disorders. Rabeprazole treats gastro-oesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. The compound exhibits hygroscopic properties, to be specific. Rabeprazole sodium, also known as Rabeprazole sodium salt, is preferred by manufacturers in the pharmaceutical industry for the production of oral dosage forms, such as enteric-coated tablets and capsules, designed to treat...

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Pharmaceutical

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Pharmaceutical Actives & Precursors

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Active Pharmaceutical Ingredients (APIs)

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Chemical Properties & Specifications

Applications of Rabeprazole Sodium

Treatment of (GERD)

Used to alleviate symptoms and promote healing in patients with GERD by reducing gastric acid secretion.

Management of (PUD)

Aids in the healing of duodenal and gastric ulcers by inhibiting acid production.

Eradication of Helicobacter pylori Infection

Employed as part of combination therapy to eliminate H. pylori, reducing the risk of ulcer recurrence.

Treatment of Zollinger-Ellison Syndrome

Manages pathological hypersecretory conditions by suppressing excessive gastric acid production.

Formulation in Delayed-Release Tablets

Commonly formulated in enteric-coated tablets to ensure stability and targeted release in the intestine.

Mechanism of Action

Irreversibly binds to and inhibits the H⁺/K⁺-ATPase enzyme system, leading to prolonged suppression of gastric acid secretion.

Bioavailability

Approximately 52% following oral administration.

Protein Binding

Approximately 96.3%.

Metabolism

Extensively metabolized in the liver via CYP2C19 and CYP3A4 isoenzymes.

Elimination Half-Life

Approximately 1 hour.

Excretion

Primarily excreted in urine as metabolites.

Pharmacopoeial Standards: Complies with USP, EP, and BP specifications.

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