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We are one of the leading manufacturers, distributors, and suppliers of Polysorbate 80 in USA. Its CAS Number is 9005-65-6, and the chemical formula is (C64H124O26)n-multiple grades.
Polysorbate 80, also known as Tween 80, is a nonionic surfactant and emulsifier widely used in industrial applications to blend oil and water-based ingredients. It acts as a useful solubilizer and emulsifier. Polysorbate 80 is commonly used in pharmaceuticals, cosmetics, and food products. As a leading Polysorbate 80 manufacturer in the US, we produce high-purity Tween 80 that meets US standards and certifications, including TSCA and NSF (Wherever applicable). For U.S. manufacturers considering buying polysorbate 80 in bulk, understanding its precise properties is crucial. Polysorbate 80 has a molecular weight of around 1,310 g/mol, and polysorbate 80 has a density of approximately 1.07 g/mL at 25°C. For detailed handling, storage, and emergency information, please refer to our Polysorbate 80 SDS or MSDS in the document section. As a renowned polysorbate 80 supplier and manufacturer in the USA, we offer competitive pricing (USD) and 55lb drum packaging for standard applications, as well as 440 lb barrels for bulk industrial use. Scimplify ensures reliable lead times across U.S regions through our efficient logistics and supply chain teams.
Polysorbate 80, also known as Tween 80, is a nonionic surfactant and emulsifier widely used in industrial applications to blend oil and water-based ingredients. It acts as a useful solubilizer and emulsifier. Polysorbate 80 is commonly used in pharmaceuticals, cosmetics, and food products. As a leading Polysorbate 80 manufacturer in the US, we produce high-purity Tween 80 that meets US standards and certifications, including TSCA and NSF (Wherever applicable). For U.S. manufacturers considering buying polysorbate 80 in bulk, understanding its precise properties is crucial. Polysorbate 80 has a molecular weight of around 1,310 g/mol, and polysorbate 80 has a density of approximately 1.07 g/m...
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Oleochemicals
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Surfactants
Non-ionic Ethoxylates
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Chemical Properties & Specifications
Polysorbate 80 is a key food-grade emulsifier that enhances consistency and extends the shelf life of processed foods. In the U.S. food sector, it is widely used in ice creams, whipped toppings, bakery mixes, sauces, and dressings, where it helps maintain a smooth texture and prevents ingredient separation.
Polysorbate is used as a surfactant and emulsifier to blend oil and water components, enabling smooth, uniform lotions and creams. It enhances product stability and texture.
In U.S. pharmaceutical formulations, Polysorbate 80 is used as a solubiliser, stabiliser, and dispersing agent for injectable drugs, vaccines, and oral liquids. It improves ingredient dispersion and protects biologics from aggregation.
In industrial processes, Polysorbate 80 plays a role as a wetting agent, dispersant, and emulsifier in coatings, paints, lubricants, agricultural sprays, and other chemical blends aimed at U.S. manufacturing applications
For laboratories and biotech firms in the U.S., Polysorbate 80 is used to solubilize APIs, stabilise proteins, and act as a surfactant in cell culture, reagent preparation, and diagnostic formulations.
Polysorbates undergo degradation by auto-oxidation, producing reactive peroxides, in addition to hydrolysis. Exposure to light of polysorbate 80 aqueous solution leads autoxidation of the alkyl polyoxyethylene chain leading to the production of hydroperoxide derivatives. The peroxides cause oxidative damage to the protein molecule that makes up the formulation. The residual peroxides and the rate of peroxide generation as a result of light exposure are found to vary for polysorbate 80 of different grades/from different sources.
Store at room temperature (15–30°C or 59–86°F)
25 kg drums, 200 kg barrels, customized packaging for pharma & food applications
Critical in stabilizing biologics in vaccine formulations (COVID-19 vaccines, flu vaccines). Acts as a solubilizing agent, preventing aggregation of sensitive biologics. Helps keep vaccines stable and effective, improving vaccine shelf life and safety.
Widely used as an emulsifier and solubilizer in pharmaceutical injectables, food emulsions, and cosmetic formulations. Key for enhancing solubility and stability of hydrophobic compounds in drug formulations and biological products like vaccines. Found in ice creams, salad dressings, and cosmetics like lotions and shampoos for better texture and consistency.
Recognized as GRAS by the US FDA and compliant with global regulatory bodies for food and pharma. Demonstrated low toxicity and high biocompatibility in preclinical and clinical studies. Commonly used in food and skincare products, considered safe and well-tolerated when used as directed.
Polysorbates are widely used to protect biological drug products from protein unfolding, aggregation, and precipitation during both shipping and handling. The polysorbates are amphipathic, nonionic surfactants made of fatty acid esters of polyoxyethylene sorbitan. Polysorbate 80 is one of the most common surfactants currently used in the formulation of protein-based biopharmaceuticals.
Polysorbate 80 is one of the primary components of protein formulations. This drug inhibits interfacial damage of the protein molecule that undergoes mechanical stress during shipping and handling. Polysorbate 80 also affects the formulation photostability. Exposure to light of polysorbate 80 aqueous solution results in peroxide generation, which in turn may lead to oxidation of the susceptible amino acid residues in the protein molecule. One study on rats found that Polysorbate 80 increased apical to basolateral membrane permeability of digoxin in Caco-2 cells suggesting that Ps 80 is an in vitro inhibitor of P-glycoprotein. It concluded that PS 80 may influence in vivo absorption of P-gp substrates, and this could be translated to human applications.
A mixture of the partial esters of sorbitol and its mono- and dianhydrides with edible commercial oleic acid and condensed with approximately 20 moles of ethylene oxide per mole of sorbitol and its anhydrides
Glycols, polyethylene, ether with sorbitan monooleate (8CI), Sorbitan, mono-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs., (Z)- (ZCI), Sorbitan, monooleate, polyoxyethylene derivs. (8CI), Admul T 80K, Agnique SMO 20, Agnique SMO 20u, Alkamuls PSMO 20, Alkamuls T 80, Alkest TW 80, Anapoe 80, Atlox 1087, Atlox 8916TF, Blaunon OT 106, Canarcel TW 80, Capmul POE-O, Cemerol T 80, Cemesol TW 1020, Crill 10, Crill 11, Crill S 10, Crillet 4, Crillet 4 Super, Crillet 41, Crillet 4HP, Crodalan AWS, Dehydat 8820, DF 80, Disponil SMO 120, Disponil SMO 120 Spez, Disponil SMO 20, Durfax 80, E 433, E 433 (polyglycol), Ecostep SE 11, Ecoteric 20, Ecoteric T 20, Ecoteric T 80, Emalex ET 8020, Emalex ET 8040, Emasol O 105R, Emasol O 120V, Emsorb 6900, Emulson 10OM, Ethoxylated sorbitan monooleate, Ethsorbox O 20, Ethylan GE 08, Ethylene oxide-sorbitan monooleate polymer, Etravon, Eumulgin SMO 20, Flo Mo SMO 20,
Yes, you can purchase Polysorbate 80 in bulk quantities in USA.
