

N,N Carbonyldiimidazole (CDI) is a high-purity carbonyl activating agent and organic coupling reagent widely used in pharmaceutical, biotechnology, and specialty chemical manufacturing. Chemically classified as a carbonyl diimidazole compound, it functions by activating carboxylic acids to form reactive imidazolide intermediates, enabling efficient amide, ester, carbamate, and urea bond formation under mild conditions without direct biological receptor interaction. Extensively applied in peptide synthesis, API and advanced intermediate production, protein modification, bioconjugation, and nucleic acid derivative synthesis, CDI serves as a synthetic reagent rather than a therapeutic substance. Supplied as a white to off-white crystalline solid, it offers high selectivity, controlled reactivity, and moisture-sensitive physicochemical properties suitable for regulated environments. Each batch undergoes comprehensive quality control including assay, melting range, and impurity profiling, and is supported with Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability documentation. As an established manufacturers and suppliers of N,N Carbonyl diimidazole in the USA, we ensure scalable supply from R&D to commercial volumes with consistent batch performance and reliable lead times with competitive prices (USD).


N,N Carbonyldiimidazole (CDI) is a high-purity carbonyl activating agent and organic coupling reagent widely used in pharmaceutical, biotechnology, and specialty chemical manufacturing. Chemically classified as a carbonyl diimidazole compound, it functions by activating carboxylic acids to form reactive imidazolide intermediates, enabling efficient amide, ester, carbamate, and urea bond formation under mild conditions without direct biological receptor interaction. Extensively applied in peptide synthesis, API and advanced intermediate production, protein modification, bioconjugation, and nucleic acid derivative synthesis, CDI serves as a synthetic reagent rather than a therapeutic substance...
Pharmaceutical
Pharmaceutical Actives & Precursors
Intermediates & Precursors
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Chemical Properties & Specifications
H302, H315, H319, H332
P261, P280, P304 + P340
Acute toxicity, oral (Category 4), Skin irritation (Category 2), Eye irritation (Category 2A)
6.1B - Harmful substance, not a primary fire risk
Primary coupling agent for amino acid activation with minimal racemisation
Essential for the synthesis of antibiotics, anti-inflammatory drugs, and complex bioconjugates
Converts amines into ureas and carbamates, and alcohols into esters
Facilitates the activation of phosphates and the synthesis of nucleic acid derivatives
Cross-linking agents & for surface functionalisation in advanced material science
Store at 20–25°C (68–77°F).
Keep in a cool, dry place away from light and moisture.
Use airtight containers to prevent contamination and degradation.
Bulk Quantities: Available in bulk for industrial and research use, typically ranging from 1 kg to 100 kg containers.