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Lamotrigine (CAS NO : 84057-84-1)

Lamotrigine is a broad-spectrum antiepileptic drug (AED) that belongs to the phenyltriazine class. It acts by inhibiting voltage-gated sodium channels, thereby stabilizing neuronal membranes and reducing excitatory neurotransmitter release, particularly glutamate. This mechanism provides efficacy across a variety of seizure types and makes it a valuable option in bipolar disorder maintenance therapy. It is administered orally and is known for its favorable bioavailability, metabolic stability, and low risk of weight gain or sedation. High-purity Lamotrigine, phenyltriazine anticonvulsant.

Lamotrigine
Lamotrigine

Lamotrigine is a broad-spectrum antiepileptic drug (AED) that belongs to the phenyltriazine class. It acts by inhibiting voltage-gated sodium channels, thereby stabilizing neuronal membranes and reducing excitatory neurotransmitter release, particularly glutamate. This mechanism provides efficacy across a variety of seizure types and makes it a valuable option in bipolar disorder maintenance therapy. It is administered orally and is known for its favorable bioavailability, metabolic stability, and low risk of weight gain or sedation. High-purity Lamotrigine, phenyltriazine anticonvulsant.

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Pharmaceutical

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Pharmaceutical Actives & Precursors

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Active Pharmaceutical Ingredients (APIs)

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Chemical Properties & Specifications

Applications of Lamotrigine

Antiepileptic & Mood Stabilizing API

Used in the manufacture of oral dosage forms to treat focal seizures, generalized tonic-clonic seizures, and Lennox–Gastaut syndrome. Also utilized as a long-term mood stabilizer in bipolar I disorder.

Broad CNS Efficacy

Effective across multiple seizure types and bipolar disorder

High Oral Bioavailability

≥98% absorption with minimal first-pass metabolism

Long Elimination Half-Life

24–35 hours, supporting once-daily dosing in many cases

Low Drug Interaction Potential

Not a CYP inducer or inhibitor

Chemically Stable

Resistant to hydrolysis and oxidation under standard conditions

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