

Diethoxymethane (CAS 462-95-3) is gaining significant traction in the API intermediates market as a sustainable, green alternative to traditional chlorinated solvents like dichloromethane, particularly for the O-alkylation of phenols and as a versatile formaldehyde equivalent in complex organic synthesis. As a leading bulk chemical supplier, we see CDMOs increasingly adopting Ethylal (CAS 462-95-3) to meet stringent regulatory compliance and sustainability mandates, leveraging its low toxicity and biodegradable profile to optimize high-purity fine chemical production (Pharma/API purity 99% | General Industry purity 98%). Diethyl formal (CAS 462-95-3) has become a critical component in custom synthesis services for the pharmaceutical industry, serving as an ethoxy transfer agent and specialized carrier for organometallics, with global sourcing shifts driving demand for manufacturers who provide robust analytical validation and impurity profiling. We are an established global intermediates supplier offering >= 99% purity to ensure minimal carry-over of impurities in the final API. We provide a broad range of pharmaceutical intermediates for API manufacturers and finished formulators, offering comprehensive analytical support (HPLC/NMR/MS) and region-specific regulatory documentation, including Ethylal COA, TDS, and SDS, alongside reliable lead times and worldwide supply chain capabilities.


Diethoxymethane (CAS 462-95-3) is gaining significant traction in the API intermediates market as a sustainable, green alternative to traditional chlorinated solvents like dichloromethane, particularly for the O-alkylation of phenols and as a versatile formaldehyde equivalent in complex organic synthesis. As a leading bulk chemical supplier, we see CDMOs increasingly adopting Ethylal (CAS 462-95-3) to meet stringent regulatory compliance and sustainability mandates, leveraging its low toxicity and biodegradable profile to optimize high-purity fine chemical production (Pharma/API purity 99% | General Industry purity 98%). Diethyl formal (CAS 462-95-3) has become a critical component in custom...
Industrial Chemicals
Solvents & Carriers
Ethers & Ether-Based Solvents
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Chemical Properties & Specifications
P210, P233, P240, P241, P242, P243, P261, P264, P280, P303+P361+P353, P305+P351+P338, P332+P313, P337+P313, P362, P370+P378, P403+P235, and P501
Flam. Liq. 2 (100%)
Skin Irrit. 2 (100%)
A versatile and high-purity solvent, also known as diethoxymethane, utilized in various industrial and professional applications for dispersing organic and inorganic pigments and fillers in aqueous and solvent-based systems
A critical organic building block employed in the manufacturing of other substances and the formulation of chemical preparations
A functional additive used in aqueous industrial, wood, decorative, and printing ink formulations to improve pigment wetting, enhance rheological stability, and provide lower viscosity with higher gloss
A high-performance component used in the formulation of specialized cleaning agents, thinners, and paint removers
A high-purity chemical used for synthesis and academic research as a sustainable, greener alternative solvent.
Ethylal, also known as diethoxymethane, is a versatile acetal solvent and chemical intermediate used in organic synthesis, particularly as a substitute for dichloromethane and toluene in O-alkylation reactions
It is widely utilized in the pharmaceutical, fragrance, and chemical manufacturing industries for synthesis, as a specialized solvent, and in the production of coatings, paints, and adhesives
Ethylal is compatible with liquid-phase protocols, acting as an excellent solvent for organolithium compounds and a surface tension reducer in various resin systems
Standard specifications include CAS number 462-95-3, purity (typically ≥99%), density, and boiling point, with documentation such as COA, TDS, impurity reports, and regulatory compliance documents available
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.