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Pregabalin is the (S)-isomer of 3-isobutyl-gamma-aminobutyric acid. Therapeutic efficacy of Pregabalin is strictly dependent on its enantiomeric purity, as the (R)-enantiomer is biologically inactive. Pregabalin is an anticonvulsant therapeutic medication primarily used to treat neuropathic pain, fibromyalgia, seizures, and generalized anxiety disorder. 3-isobutyl GABA functions by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, inhibiting excitatory neurotransmitter release. As a blockbuster agent for Neuropathic Pain, Generalized Anxiety Disorder (GAD), and Partial Seizures, its manufacturing requires extreme stereochemical precision. We utilise world-class manufacturing infrastructure, employing either enzymatic kinetic resolution or asymmetric hydrogenative catalysis to achieve near-perfect stereoselectivity - free from chiral impurities - meets the most stringent global pharmacopoeial standards (USP/EP/BP/IP). Our high-performance Pregabalin API is a gold-standard gabapentinoid, meticulously synthesised for the global pharmaceutical sector as we are an established pregabalin api supplier with Pregabalin high purity. Our process chemistry is designed for low residual solvent profiles and a controlled impurity fate, making it the preferred choice for top-tier CDMOs and pharmaceutical formulators.
Pregabalin is the (S)-isomer of 3-isobutyl-gamma-aminobutyric acid. Therapeutic efficacy of Pregabalin is strictly dependent on its enantiomeric purity, as the (R)-enantiomer is biologically inactive. Pregabalin is an anticonvulsant therapeutic medication primarily used to treat neuropathic pain, fibromyalgia, seizures, and generalized anxiety disorder. 3-isobutyl GABA functions by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, inhibiting excitatory neurotransmitter release. As a blockbuster agent for Neuropathic Pain, Generalized Anxiety Disorder (GAD), and Partial Seizures, its manufacturing requires extreme stereochemical precision. We...
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Active Pharmaceutical Ingredients (APIs)
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Chemical Properties & Specifications
H302, H315, H319
P261, P264, P270, P280, P301+P312, P305+P351+P338 P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Limited information regarding overdose with pregabalin. The highest known accidental overdose of pregabalin during clinical development was 8000 mg; this event was without significant clinical consequences. The most commonly reported adverse events with overdose were reduced consciousness, confusional state, agitation, depression/anxiety, and restlessness in the postmarketing studies. In addition, heart block, seizures, and death have also been reported in some patients taking combination with other CNS depressants.
Pregabalin can be removed by standard haemodialysis procedures, resulting in approximately 50% clearance of pregabalin in 4 hours.
Pain treatment associated with diabetic peripheral neuropathy, postherpetic neuralgia, and spinal cord injury
Adjunct therapy for partial-onset seizures and generalised anxiety disorder, enhancing overall seizure control.
Provides relief from fibromyalgia-related pain, stiffness, and sleep disturbances.
Store at 25 °C (77 °F); excursions permitted to 15 to 30 °C (59 to 86 °F). Maintain it in cool, dry, well-ventilated area, away from moisture and incompatible substances.
Available in various sizes, including 25 kg double poly bags within HDPE drums for bulk applications.