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3-(4-Chlorophenyl)Isoindolin-1-one (CAS NO : 2224-77-3)

Our 3-(4-Chlorophenyl)Isoindolin-1-one is a high-purity crystalline intermediate belonging to the isoindolinone family. This compound is an essential "platform molecule" used in the multi-step synthesis of various tricyclic sympathomimetic agents, most notably Mazindol. Specialised heterocyclic organic building block primarily utilised as a high-value pharmaceutical intermediate & recognised as a key precursor in the synthesis of Mazindol (a potent anorexiant/appetite suppressant) and is also a documented impurity standard for the diuretic medication Chlorthalidone. In 2026, Phthalimidine, 3-(p-chlorophenyl)- is also highly sought after by quality control laboratories as a reference standard for Chlorthalidone impurity profiling. Featuring a robust chemical structure with a chlorophenyl substitution, it provides a stable foundation for a broad spectrum of biological activities, including antimicrobial and anxiolytic research. We offer this product at 98%+ purity, backed by comprehensive analytical data (NMR, HPLC) to support global API manufacturing and research requirements. We are globally established pharmaceutical suppliers, right from intermediate to semi-finished formulations / dosages, ensuring reliable lead times; comprehensive regulatory documentation (CoA); and consistent worldwide supply capabilities across all grades/forms/strengths.

3-(4-Chlorophenyl)Isoindolin-1-one
3-(4-Chlorophenyl)Isoindolin-1-one

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COA

Our 3-(4-Chlorophenyl)Isoindolin-1-one is a high-purity crystalline intermediate belonging to the isoindolinone family. This compound is an essential "platform molecule" used in the multi-step synthesis of various tricyclic sympathomimetic agents, most notably Mazindol. Specialised heterocyclic organic building block primarily utilised as a high-value pharmaceutical intermediate & recognised as a key precursor in the synthesis of Mazindol (a potent anorexiant/appetite suppressant) and is also a documented impurity standard for the diuretic medication Chlorthalidone. In 2026, Phthalimidine, 3-(p-chlorophenyl)- is also highly sought after by quality control laboratories as a reference standard...

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Industry

Pharmaceutical

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Category

Pharmaceutical Actives & Precursors

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Sub-category

Intermediates & Precursors

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Chemical Properties & Specifications

Applications of 3-(4-Chlorophenyl)Isoindolin-1-one

API

Primary intermediate for the synthesis of Mazindol and related appetite suppressants

Impurity Profiling

Reference standard (Impurity/Related Compound) for Chlorthalidone and other isoindoline-based diuretics

Drug Discovery & Research

Scaffold in medicinal chemistry for developing new anti-arrhythmic, antimicrobial, and antipsychotic agents

Reference Standards

Utilized in its deuterium-labeled form (d₄) as an internal standard for quantitative analysis by GC-MS and LC-MS.

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