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(CAS 127892-62-0) - specialised heterocyclic building block - Agrochemical and Pharmaceutical hierarchies, a recognised as the definitive structural precursor for Tolfenpyrad, a high-efficacy pyrazole-5-carboxamide insecticide & acaricide. EMCA's architecture, featuring a halogenated pyrazole core with specific alkyl substitutions, is engineered to provide exact regioselectivity and bio-isosteric properties required for modern crop protection and (METI) chemistry. Source High-Purity 4-Chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid from Scimplify, your authoritative global manufacturer and supplier of Tolfenpyrad intermediates. A critical specialty pyrazole carboxylic acid utilised in the large-scale synthesis of Tolfenpyrad Technical, a leading insecticide known for its multi-stage pest control. Our bulk pyrazole intermediate is manufactured under stringent quality controls, ensuring the high regiochemical purity required for amide coupling in CDMO and agrochemical (AI) production. As a vital halogenated heterocycle, it provides essential backbone for developing (Mitochondrial Electron Transport Inhibitor) agents. Whether you are scaling up Tolfenpyrad manufacturing or researching next-generation pyrazole-5-carboxamide derivatives, Scimplify delivers the consistent performance, global regulatory compliance, and reliable bulk pricing necessary for global supply chain excellence.
(CAS 127892-62-0) - specialised heterocyclic building block - Agrochemical and Pharmaceutical hierarchies, a recognised as the definitive structural precursor for Tolfenpyrad, a high-efficacy pyrazole-5-carboxamide insecticide & acaricide. EMCA's architecture, featuring a halogenated pyrazole core with specific alkyl substitutions, is engineered to provide exact regioselectivity and bio-isosteric properties required for modern crop protection and (METI) chemistry. Source High-Purity 4-Chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid from Scimplify, your authoritative global manufacturer and supplier of Tolfenpyrad intermediates. A critical specialty pyrazole carboxylic acid utilised in ...
Chemical Properties & Specifications
Skin Irrit. 2 (100%), Eye Irrit. 2 (100%), STOT SE 3 (50%)
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Production of Tolfenpyrad. Acid intermediate is reacted with 4-(4-methylphenoxy)benzylamine (TOBA) to form the final amide bond. Tolfenpyrad is highly effective against a broad spectrum of pests, including thrips, aphids, and mites in vegetables, fruits, and teacrops
Substituted pyrazoles are privileged scaffolds in medicinal chemistry. Specific carboxylic acid is used in drug discovery to explore COX-2 inhibitors and other enzyme-targeting therapies where a chloro-pyrazole moiety is needed for optimized binding affinity
Reagent in the creation of complex nitrogen-containing molecules where the 4-chloro substitution acts as a site for further functionalization via cross-coupling reactions
Stable under standard conditions
Carboxylic acid group is stable but should be protected from strong bases to avoid salt formation during storage
Store in a cool, dry, and well-ventilated area (15°C to 25°C)
Keep containers tightly closed and away from moisture to prevent degradation
This acid (CAS 127892-62-0) represents the "left-hand" portion of the Tolfenpyrad molecule. Securing a high-purity supply is critical because the purity of this intermediate directly dictates the yield and impurity profile of the final Tolfenpyrad Technical. Scimplify ensures the chloro-substitution at the 4-position is precise, preventing off-target isomers
We utilize validated Reverse-Phase HPLC and GC-MS during our in-process quality control. We monitor for the 4-deschloro and 4-nitro precursors to ensure the final intermediate meets the ≥ 98.0% assay standard required for seamless amide coupling.
Our standard crystalline powder is optimized for rapid dissolution in common organic solvents (like Toluene or DCM) used in amide bond formation. If your process requires a specific micronized grade or a specialized PSD (Particle Size Distribution), we can customize the finishing steps to meet your reactor specifications.
Yes. We provide complete documentation, including GHS-compliant SDS, (COA), and TSCA/REACH status (If applicable). Our logistics team is experienced in handling specialized agrochemical intermediates for the US, EU, and Asian markets, ensuring reliable lead times.
The moq to buy Pyrazole-5-carboxylic acid Intermediate bulk shared with procurement managers
The 4-Chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid Price 2026 shared upon sourcing with export documentation adhering region specific compliances.
