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4-(4-Methylphenoxy)benzylamine hydrochloride (CAS 262862-66-8), commonly referred to as TOBA HCl, is a high-purity aromatic amine salt. In Elemental Derivatives and Pharmaceutical hierarchy, it serves as the indispensable structural building block for the synthesis of Vortioxetine (an atypical antidepressant). TOBA HCl's architecture, featuring a phenoxyphenyl core and a terminal primary amine, makes it a critical node for N-arylation reactions in the production of multi-modal serotonergic agents. Our bulk TOBA HCl is manufactured under stringent quality controls, ensuring low impurity profiles and high crystalline stability for CDMO and large-scale API manufacturing. As a critical aromatic amine intermediate, it offers exceptional regioselectivity in palladium-catalysed coupling reactions. Whether you are developing next-generation CNS therapies or advanced agrochemical actives, our TOBA HCl provides the consistent performance and reliable lead times required for global supply chain excellence.
4-(4-Methylphenoxy)benzylamine hydrochloride (CAS 262862-66-8), commonly referred to as TOBA HCl, is a high-purity aromatic amine salt. In Elemental Derivatives and Pharmaceutical hierarchy, it serves as the indispensable structural building block for the synthesis of Vortioxetine (an atypical antidepressant). TOBA HCl's architecture, featuring a phenoxyphenyl core and a terminal primary amine, makes it a critical node for N-arylation reactions in the production of multi-modal serotonergic agents. Our bulk TOBA HCl is manufactured under stringent quality controls, ensuring low impurity profiles and high crystalline stability for CDMO and large-scale API manufacturing. As a critical aromatic ...
Chemical Properties & Specifications
Phenoxyphenyl-methylamine scaffold - privileged structure in the development of novel Fungicides and Herbicides that target specific enzyme sites in plant pathogens, utilizing the ether-linked aromatic rings for optimized lipophilicity
Significant in Synthesis of Vortioxetine Hydrobromide. TOBA HCl-coupled with 2-(2,4-dimethylphenylthio)benzene derivatives to form the core of the antidepressant molecule
Functionalizing agent in the creation of specialized polymers and resins where an aromatic ether-linked amine moiety is required to enhance thermal or chemical resistance
Stable under recommended storage conditions
Sensitive to prolonged exposure to air and moisture which may lead to carbonate formation of the amine
Store in a cool, dry, well-ventilated area. Keep containers tightly closed
Recommended storage temperature: 15°C to 25°C
HCl salt form (CAS 262862-66-8) is significantly more stable, crystalline, and easier to handle in a production environment compared to the free base, which can be prone to oxidation and carbon dioxide absorption. This ensures higher titer and longer shelf life.
Our TOBA HCI is dried to a moisture content of ≤ 0.5%. Low moisture is critical for subsequent N-arylation or amidation steps where water can quench reactive catalysts or intermediates, leading to reduced yields.
Our process minimizes the presence of 4-methylphenol (p-cresol) and residual benzyl chloride derivatives. We maintain total impurities at < 1.0%, with individual unknown impurities below 0.10%, supporting seamless integration into validated API processes.
With our optimized synthesis route and robust inventory management, we offer reliable lead times ranging from 4 to 8 weeks for bulk global shipments, ensuring your API production timelines remain uninterrupted.
Yes export ready with TOBA hcl coa, TOBA
