2-chloro-5-chloromethylthiazole

CAS Number: 105827-91-6

Molecular Formula: C4H3Cl2NS

2-chloro-5-chloromethylthiazole manufacturerbuy 2-chloro-5-chloromethylthiazolethiamethoxam intermediate supplierclothianidin intermediate pricepharmaceutical grade 2-chloro-5-chloromethylthiazole98% purity 2-chloro-5-chloromethylthiazole

About 2-chloro-5-chloromethylthiazole

2-Chloro-5-thiazolylmethyl chloride (CAS 105827-91-6) serves as a critical heterocycle in the API intermediates market, functioning as the foundational building block for the synthesis of Ritonavir, a second-generation HIV protease inhibitor. As CDMOs increasingly focus on high-purity fine chemicals (Pharma/API purity ...

2-chloro-5-chloromethylthiazole Specifications

CAS Number

105827-91-6

Molecular Formula

C4H3Cl2NS

Molecular Weight

168.04 g/mol

IUPAC Name

2-chloro-5-(chloromethyl)-1,3-thiazole

Canonical SMILES

C1=C(SC(=N1)Cl)CCl

InChI Key

VRMUIVKEHJSADG-UHFFFAOYSA-N

InChI

InChI=1S/C4H3Cl2NS/c5-1-3-2-7-4(6)8-3/h2H,1H2

EINECS Number

429-830-5

MDL Number

MFCD01073549

HSN No

29341000

CAS Number

105827-91-6

Molecular Formula

C4H3Cl2NS

Molecular Weight

168.04 g/mol

IUPAC Name

2-chloro-5-(chloromethyl)-1,3-thiazole

Canonical SMILES

C1=C(SC(=N1)Cl)CCl

InChI Key

VRMUIVKEHJSADG-UHFFFAOYSA-N

InChI

InChI=1S/C4H3Cl2NS/c5-1-3-2-7-4(6)8-3/h2H,1H2

EINECS Number

429-830-5

MDL Number

MFCD01073549

HSN No

29341000

Molecular Weight

168.04 g/mol

Melting Point

31°C

Boiling Point

268.6 °C at 760 mmHg

Freezing point

29-31°C

Flash Point

116.3 °C

Density

1.503±0.06 g/cm3

pKa

0.19±0.10(Predicted)

PSA

41.1 Å²

logP

2.3

Average mass

168.04 g/mol

Monoisotopic mass

166.9363257 Da

Molar mass

168.04 g/mol

Vapour pressure

0.0126mmHg at 25°C

Precautionary Statement Codes

P260, P273, P280, P301+P312, P303+P361+P353, P305+P351+P338, P304+P340+P310, P301+P330+P331, P308+P313, P333+P313, P361+P364, P391, P405, and P501

Hazard Classes and Categories

Acute Tox. 3 Dermal Acute Tox. 4 Oral

Pharmaceutical Intermediate

2-Chloro-5-chloromethylthiazole serves as a critical building block in the synthesis of pharmaceuticals, most notably Ritonavir, a second-generation anti-AIDS drug and selective HIV protease inhibitor used in viral treatment

Agrochemical Intermediate

The compound is a key precursor for manufacturing next-generation neonicotinoid insecticides such as Thiamethoxam and Clothianidin, providing high-efficiency pest control for sustainable agriculture

Organic Synthesis

It is utilized as a versatile heterocyclic building block in specialty chemical research for introducing thiazole moieties into complex molecules, antifungal agents, and advanced materials with properties like flame retardancy.