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Folic Acid, also known as Vitamin B9, is a water-soluble B-vitamin essential for DNA repair, red blood cell formation, and amino acid metabolism. Because Folic Acid is used in milligram dosages, achieving a perfectly homogenous blend in large-scale production is a significant technical challenge. Vitamin M is crucial precursor to tetrahydrofolate (THF) - active form nutrient - preferred in supplements and food fortification because of its superior chemical stability & high bioavailability compared to natural folates. Compound's versatility is confined to the pharmaceutical and nutraceutical industries, where it is globally mandated for public health interventions, primarily to prevent neural tube defects (NTDs) during early pregnancy and to treat deficiency-related megaloblastic anaemia. Also referred to as Pteroylglutamic Acid & Vitamin B9 by folic acid suppliers & manufacturers, respectively. We utilise world-class manufacturing infrastructure, with standards on par with global leaders like DSM and BASF, to deliver Folic Acid in specialised (ME & NGLP) formats at 10% and 20% strengths. Our high-performance Folic Acid (Vitamin B9) portfolio is specifically engineered for precision nutritional fortification and pharmaceutical stability, targeting critical life stages and cellular health. We are globally established nutraceutical suppliers, ensuring reliable lead times and quality assurance through comprehensive regulatory documentation (Folic Acid CoA) across all grades/forms/strenghts.
Folic Acid, also known as Vitamin B9, is a water-soluble B-vitamin essential for DNA repair, red blood cell formation, and amino acid metabolism. Because Folic Acid is used in milligram dosages, achieving a perfectly homogenous blend in large-scale production is a significant technical challenge. Vitamin M is crucial precursor to tetrahydrofolate (THF) - active form nutrient - preferred in supplements and food fortification because of its superior chemical stability & high bioavailability compared to natural folates. Compound's versatility is confined to the pharmaceutical and nutraceutical industries, where it is globally mandated for public health interventions, primarily to prevent neural...
Chemical Properties & Specifications
"Gold Standard" for Preventing Neural Tube Defects (NTDs)
Prenatal vitamins and B-complex supplements for its critical role in cell division and genetic repair
High tableting recovery (95–98%), a crucial factor for MNCs ensuring that the high-potency, low-dose active survives industrial compression. Prescription medications to treat megaloblastic and macrocytic anemias caused by folate deficiency
Formulations designed to manage Homocysteine levels, supporting heart health and reducing stroke risk
Fortification of flour, rice, and cereals. Our micro-encapsulated form ensures stability against high baking temperatures and processing
Micronutrient in developmental vitamins and infant formulas to support rapid cell division and growth
Cell culture media (e.g., Minimum Essential Medium, MEM) as a necessary growth factor
Research preferrance as a ligand in studies of folate-binding proteins
Chosen for fortification because it exhibits greater stability (heat, light, and oxidation resistance) and has higher bioavailability than the naturally occurring folates found in green vegetables, ensuring a consistent and reliable dosage.
Most common grades are USP/EP for pharmaceutical & high-end supplement manufacturing, or Food Grade for fortification.
Folic Acid is the synthetic, inactive precursor. 5-MTHF is the bio-active, reduced form (often referred to as 'L-methylfolate') that is directly utilized by the body and is often preferred in supplements for individuals with genetic variations (like MTHFR polymorphism) that impair the conversion of Folic Acid to its active form.
Once converted to THF, serves as a one-carbon donor (a methyl group) in the pathway that converts deoxyuridine monophosphate (UMP) to deoxythymidine monophosphate (dTMP), which is a precursor required for DNA replication and repair.
Pure Folic Acid has poor flow properties and a tendency to "clump," leading to dosing inaccuracies (hot spots) in tablets. Our 10% and 20% ME powders provide a standardized, free-flowing matrix. This ensures every single tablet or serving contains the exact micro-dose required, which is critical for safety in prenatal and infant nutrition.
Folic Acid is sensitive to light, oxygen, and high heat. Our Micro-encapsulation (ME) shields the active molecule within a protective food-grade coating (Modified Starch/Gum Acacia). This technology ensures maximum assay retention even through rigorous processes like flour milling, bread baking, or high-heat extrusion in cereals.
Yes. Our Folic Acid ME is optimized for a high tableting recovery of 95–98%. For MNCs, this means the micro-capsules are engineered to withstand the mechanical pressure of high-speed presses without rupturing, preventing the active from being exposed to degradants during the shelf life of the tablet.
We are an end-to-end partner. We provide full regulatory and documentation support (CoA, traceability). Buyers receive data packages including 3-month accelerated and 6-month real-time stability studies, assay retention %, and solubility videos to verify performance in liquid premixes.
We offer a significantly lower lead time of 4–6 weeks, compared to the 10–14 weeks standard of global suppliers. Our commercial models include tier pricing, annual contract pricing, and campaign-based pricing to provide maximum cost efficiency for long-term partners.
One of the risks in pharma manufacturing is "active segregation," where low-dose APIs like Folic Acid separate from bulk excipients during vibration or flow. Our ME technology utilizes Controlled Particle Size Distribution (PSD) and high bulk density to match common fillers (like MCC or Lactose). This ensures a perfectly homogenous blend and prevents "hot spots," allowing manufacturers to meet the strict Content Uniformity (CU) requirements of pharmacopoeial standards (USP/EP) even at high production speeds.
We are an end-to-end partner. We provide full regulatory and documentation support (CoA, traceability). Our Folic Acid is tested for related substances and degradation products to ensure it meets the highest API purity standards. Because Folic Acid is highly susceptible to photo-oxidation and cleavage, our Micro-encapsulation serves as a functional barrier. This results in a superior Assay Retention of 95-98% over 24 months. We provide comprehensive analytical support, including 3-month accelerated and 6-month real-time stability data, specifically for R&D managers evaluating shelf-life stability in multi-component formulations.
